Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2919354 | 0.81 | LMNA (0.63) | LMNADYRK1AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL21403473 | 0.80 | KDM4E (0.56) | LMNADYRK1AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2955695 | 0.78 | LMNA (0.63) | LMNADYRK1AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3226572 | 0.77 | TYMS (0.63) | LMNASMN1; SMN2POLBRAB9ANPC1 | |
| SCHEMBL29440611 | 0.77 | TYMS (0.63) | LMNASMN1; SMN2POLBRAB9ANPC1 | |
| SCHEMBL21089735 | 0.76 | PTGES (0.41) | MEN1KMT2ASMN1; SMN2RAB9APTGES | |
| SCHEMBL12509441 | 0.76 | FGFR1 (0.53) | LMNADYRK1AMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL12509440 | 0.76 | ALDH1A1 (0.49) | LMNAMEN1KMT2ASMN1; SMN2POLB | |
| SCHEMBL31153423 | 0.74 | KDM4E (0.46) | MEN1KMT2ARAB9ANPC1PTGES | |
| SCHEMBL13343607 | 0.74 | KDM4E (0.46) | MEN1KMT2ARAB9ANPC1PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018086585-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATIONS THEREOF | 山东罗欣药业集团股份有限公司 | 2018-05-17 | — | — | WO | disclosed |
| EP-2270002-A1 | Quinazoline derivatives as histamine H4-receptor inhibitors for use in the treatment of inflammatory disorders | Vereniging voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patiëntenzorg (NL) | 2011-01-05 | — | — | EP | disclosed |