Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10312560 | 0.86 | CYP2C9 (0.46) | RAB9ASMN1; SMN2NPC1HTTHCAR2 | |
| SCHEMBL10312563 | 0.81 | TP53 (0.54) | RAB9ASMN1; SMN2HTTHCAR2CYP2C9 | |
| SCHEMBL4548470 | 0.79 | NPC1 (0.47) | RAB9ASMN1; SMN2NPC1HTTHCAR2 | |
| SCHEMBL13933879 | 0.77 | HCAR2 (0.48) | RAB9ASMN1; SMN2NPC1HTTHCAR2 | |
| SCHEMBL10312532 | 0.77 | MITF (0.54) | HCAR2CYP2C9ALDH1A1TP53MAPT | |
| SCHEMBL3616245 | 0.76 | NOTUM (0.58) | RAB9ASMN1; SMN2NPC1HTTALDH1A1 | |
| SCHEMBL4555562 | 0.75 | HCAR2 (0.56) | RAB9ASMN1; SMN2NPC1HTTHCAR2 | |
| SCHEMBL10312559 | 0.75 | HCAR2 (0.70) | HCAR2CYP2C9HSD11B1 | |
| SCHEMBL10312550 | 0.75 | HCAR2 (0.51) | RAB9ASMN1; SMN2NPC1HCAR2CYP2C9 | |
| SCHEMBL10312533 | 0.74 | MAPT (0.48) | SMN1; SMN2HCAR2CYP2C9ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178750-A1 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment | MERCK SHARP & DOHME CORP. (US) | 2012-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178750-A1 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment | HCAR1, HCAR2, FFAR1 | RAB9A 2712/4885SMN1; SMN2 3840/4885NPC1 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.