Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 6/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10312532 | 0.88 | MITF (0.54) | TP53MAPTHCAR2CYP2C9LMNA | |
| SCHEMBL4556041 | 0.86 | HCAR2 (0.61) | TP53RAB9AKLF5SMN1; SMN2HCAR2 | |
| SCHEMBL10312533 | 0.85 | MAPT (0.48) | SMN1; SMN2MAPTHCAR2CYP2C9LMNA | |
| SCHEMBL13920709 | 0.85 | HCAR2 (0.59) | TP53RAB9AKLF5SMN1; SMN2HCAR2 | |
| SCHEMBL10312554 | 0.81 | RAB9A (0.49) | TP53RAB9AKLF5SMN1; SMN2MAPT | |
| SCHEMBL13920697 | 0.80 | TP53 (0.53) | TP53RAB9AKLF5SMN1; SMN2MAPT | |
| SCHEMBL5206454 | 0.79 | NPC1 (0.63) | TP53RAB9AKLF5SMN1; SMN2ATM | |
| SCHEMBL4548476 | 0.79 | LMNA (0.52) | TP53RAB9AKLF5SMN1; SMN2MAPT | |
| SCHEMBL10312550 | 0.76 | HCAR2 (0.51) | RAB9ASMN1; SMN2HCAR2CYP2C9TSHR | |
| SCHEMBL13781596 | 0.74 | HCAR2 (0.65) | TP53HCAR2CYP2C9LMNAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178750-A1 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment | MERCK SHARP & DOHME CORP. (US) | 2012-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178750-A1 | Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment | HCAR1, HCAR2, FFAR1 | TP53 3377/4885RAB9A 2712/4885KLF5 2470/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.