Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | CCR1 | P32246 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.36 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | TACR1 | P25103 | 3/20 | 0.35 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ICMT | O60725 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1031266 | 0.86 | CCR1 (0.44) | CYP3A4CCR1P2RX1TMPRSS4ELANE | |
| SCHEMBL1031862 | 0.79 | MAPT (0.41) | HTTALDH1A1TP53MAPT | |
| SCHEMBL1030127 | 0.77 | KMT2A (0.39) | ALDH1A1MAPT | |
| SCHEMBL4108837 | 0.73 | MAPT (0.36) | ALDH1A1TP53MAPTICMT | |
| SCHEMBL1028564 | 0.72 | ALDH1A1 (0.38) | CYP3A4ALDH1A1TP53MAPT | |
| SCHEMBL1031886 | 0.70 | METAP2 (0.37) | ALDH1A1TP53 | |
| SCHEMBL1032752 | 0.69 | EPHX1 (0.40) | TACR1 | |
| SCHEMBL1031826 | 0.67 | PTGER4 (0.43) | TP53 | |
| SCHEMBL1028249 | 0.67 | PDE10A (0.38) | TP53MAPT | |
| SCHEMBL13818148 | 0.65 | CACNA1H (0.50) | CYP3A4HTTALDH1A1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | disclosed |