Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | WDR5 | P61964 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1032752 | 0.91 | EPHX1 (0.40) | METAP2PDE10AFAAHRIPK1 | |
| SCHEMBL1031804 | 0.81 | ALDH1A1 (0.42) | METAP2LMNAALDH1A1KMT2AWDR5 | |
| SCHEMBL1028564 | 0.81 | ALDH1A1 (0.38) | METAP2LMNAALDH1A1KMT2AWDR5 | |
| SCHEMBL1030186 | 0.74 | GAA (0.46) | LMNAALDH1A1KMT2AMEN1TP53 | |
| SCHEMBL1030127 | 0.74 | KMT2A (0.39) | METAP2LMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL1030010 | 0.74 | MAPK14 (0.50) | WDR5 | |
| SCHEMBL1031357 | 0.73 | P2RX7 (0.46) | — | |
| SCHEMBL1032170 | 0.72 | RIPK1 (0.47) | LMNAALDH1A1METRIPK1 | |
| SCHEMBL1032701 | 0.72 | ALDH1A1 (0.44) | LMNAALDH1A1TP53 | |
| SCHEMBL1031423 | 0.70 | CYP3A4 (0.40) | ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | disclosed |