⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10314776 | 1.00 | — | — | |
| SCHEMBL26441527 | 1.00 | — | — | |
| SCHEMBL16821062 | 0.81 | LMNA (0.36) | — | |
| SCHEMBL16821017 | 0.81 | LMNA (0.36) | — | |
| SCHEMBL16821014 | 0.81 | LMNA (0.36) | — | |
| SCHEMBL28555437 | 0.79 | CA1 (0.33) | — | |
| SCHEMBL28555438 | 0.79 | CA1 (0.33) | — | |
| SCHEMBL15611822 | 0.79 | CA1 (0.33) | — | |
| SCHEMBL11503420 | 0.79 | GPR84 (0.33) | — | |
| SCHEMBL15755391 | 0.75 | TSHR (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113943296-A | Pyrrolopyrimidine derivatives and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-01-18 | — | — | CN | disclosed |
| US-8865898-B2 | Nucleoside analog or salt thereof, oligonucleotide analog, gene expression inhibitor, and nucleic-acid probe for detecting gene | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2014-10-21 | — | — | US | disclosed |
| US-20140221637-A1 | NUCLEOSIDE ANALOG OR SALT THEREOF, OLIGONUCLEOTIDE ANALOG, GENE EXPRESSION INHIBITOR, AND NUCLEIC-ACID PROBE FOR DETECTING GENE | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2014-08-07 | — | — | US | disclosed |
| US-8513443-B2 | Preparation of (R)-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and (S)-N-3,4-difluoro-2(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide | ARDEA BIOSCIENCES, INC. (US) | 2013-08-20 | — | — | US | disclosed |
| US-20120178946-A1 | PREPARATION OF (R)-N-(3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMIN0)-6-METHOXYPHENYL)-1-(2,3-DIHYDROXYPROPYL)CYCLOPROPANE-1-SULFONAMIDE AND (S)- N-(3,4-DIFLUORO-2-(2-FLUORO-4-IODOPHENYLAMIN0)-6-METHOXYPHENYL)-1-(2,3-DIHYDROXYPROPYL)CYCLOPROPANE-1-SULFONAMIDE | ARDEA BIOSCIENCES ,INC. (US) | 2012-07-12 | — | — | US | disclosed |