Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 1/20 | 0.73 |
| ▸ | MPL | P40238 | 5/20 | 0.63 |
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 4/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.51 |
| ▸ | AGER | Q15109 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.45 |
| ▸ | FEN1 | P39748 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6685534 | 0.84 | TYR (1.00) | TYRLTA4HMKNK1MKNK2ALDH1A1 | |
| SCHEMBL62517 | 0.83 | MPL (0.67) | TYRMPLAGERALDH1A1ALOX5 | |
| SCHEMBL30123292 | 0.83 | MPL (0.67) | TYRMPLAGERALDH1A1ALOX5 | |
| SCHEMBL1801511 | 0.80 | MPL (0.63) | TYRMPLLTA4HALDH1A1ALOX5 | |
| SCHEMBL1689568 | 0.80 | MPL (0.63) | TYRMPLLTA4HALDH1A1ALOX5 | |
| SCHEMBL10315993 | 0.78 | TYR (0.56) | TYRMPLLTA4HMKNK1MKNK2 | |
| SCHEMBL474311 | 0.78 | MPL (1.00) | TYRMPLLTA4HALDH1A1ALOX5 | |
| SCHEMBL474246 | 0.77 | MPL (0.59) | TYRMPLALDH1A1ALOX5RAB9A | |
| SCHEMBL10315908 | 0.77 | MPL (0.56) | TYRMPLLTA4HMKNK1MKNK2 | |
| SCHEMBL21484609 | 0.76 | MPL (0.58) | TYRMPLLTA4HALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120178766-A1 | FUROPYRIMIDINEDIONE DERIVATIVES AS TRPAI MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2012-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178766-A1 | FUROPYRIMIDINEDIONE DERIVATIVES AS TRPAI MODULATORS | TRPA1, TRPV1, TRPC3 | TYR 498/4885MPL 3150/4885LTA4H 234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.