Sugi Predict

Sugi Predict / Compounds / SCHEMBL62517

SCHEMBL62517

SCHEMBL62517

Nc1nc(-c2ccc(F)cc2F)cs1

nearest known ligand 0.67

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ MPL P40238 6/20 0.67
▸ RAB9A P51151 3/20 0.58
▸ ALDH1A1 P00352 1/20 0.58
▸ ALOX5 P09917 1/20 0.58
▸ MEN1 O00255 2/20 0.56
▸ KMT2A Q03164 2/20 0.56
▸ MAPT P10636 2/20 0.56
▸ KDM4E B2RXH2 1/20 0.56
▸ TYR P14679 1/20 0.53
▸ MAOA P21397 4/20 0.51
▸ MAOB P27338 4/20 0.51
▸ AGER Q15109 2/20 0.50
▸ NPC1 O15118 2/20 0.50
▸ ALOX5AP P20292 3/20 0.47
▸ FEN1 P39748 3/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30123292 1.00 MPL (0.67) MPLRAB9AALDH1A1ALOX5MEN1
SCHEMBL29654093 0.92 MPL (0.58) MPLRAB9AALDH1A1ALOX5MEN1
SCHEMBL31006087 0.86 MPL (0.67) MPLRAB9AALDH1A1ALOX5MEN1
SCHEMBL1916792 0.86 MPL (0.67) MPLRAB9AALDH1A1ALOX5MEN1
SCHEMBL1689568 0.83 MPL (0.63) MPLRAB9AALDH1A1ALOX5MEN1
SCHEMBL1801511 0.83 MPL (0.63) MPLRAB9AALDH1A1ALOX5MEN1
SCHEMBL10315919 0.83 TYR (0.73) MPLRAB9AALDH1A1ALOX5MEN1
SCHEMBL1800902 0.83 ALDH1A1 (0.54) MPLRAB9AALDH1A1ALOX5MEN1
SCHEMBL3766113 0.82 MAOA (0.51) MPLRAB9AALDH1A1MEN1KMT2A
SCHEMBL10264427 0.81 NPC1 (0.53) RAB9AMEN1KMT2AMAPTMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 139 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118344304-A Ibuprofen derivative and preparation method and application thereof 华南农业大学 2024-07-16 — — CN disclosed
CN-116854683-A Coumarin thiazole derivative and preparation method and application thereof 中北大学 2023-10-10 — — CN disclosed
CN-115466229-A P-acylamino benzenesulfonyl compound and application thereof 上海中医药大学 2022-12-13 — — CN disclosed
CN-109293652-B Substituted thiazole derivative and application thereof 四川科伦博泰生物医药股份有限公司 2021-10-22 — — CN disclosed
EP-3354646-A1 ISOINDOLINE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER Celgene Corporation (US) 2018-08-01 — — EP disclosed
EP-2985281-B1 ISOINDOLINE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER CELGENE CORP (US) 2017-12-27 — — EP disclosed
US-9796698-B2 Isoindoline compounds and methods of their use CELGENE CORPORATION (US) 2017-10-24 — — US disclosed
US-20170217923-A1 THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2017-08-03 — — US disclosed
US-20170217923-A1 THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2017-08-03 — — US disclosed
US-9656953-B2 Inhibition of cell proliferation UNIVERSITY OF SOUTH FLORIDA (US) 2017-05-23 — — US disclosed
US-20080076771-A1 Thrombopoietin Receptor Agonists REITER LAWRENCE A 2008-03-27 — — US disclosed
EP-1874765-A2 UREA DERIVATIVES METHODS FOR THEIR MANUFACTURE AND USES THEREOF Proskelia SAS (FR) 2008-01-09 — — EP disclosed
US-20070265265-A1 N-(5-MEMBERED AROMATIC RING)-AMIDO ANTI-VIRAL COMPOUNDS GENELABS TECHNOLOGIES, INC. 2007-11-15 — — US disclosed
US-20070254318-A1 INHIBITION OF CELL PROLIFERATION NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2007-11-01 — — US disclosed
US-20070254318-A1 INHIBITION OF CELL PROLIFERATION NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2007-11-01 — — US disclosed
WO-2007070600-A2 N-(5-MEMBERED HETEROAROMATIC RING)-AMIDO ANTI-VIRAL COMPOUNDS GENELABS TECHNOLOGIES, INC. (US) 2007-06-21 — — WO disclosed
EP-1794156-A2 TROMBOPOIETIN RECEPTOR AGONISTS Pfizer Products Incorporated (US) 2007-06-13 — — EP disclosed
WO-2007062222-A2 INHIBITION OF CELL PROLIFERATION UNIVERSITY OF SOUTH FLORIDA (US) 2007-05-31 — — WO disclosed
WO-2006117211-A2 UREA DERIVATIVES METHODS FOR THEIR MANUFACTURE AND USES THEREOF PROSKELIA SAS (FR) 2006-11-09 — — WO disclosed
WO-2006033005-A2 THROMBOPOIETIN RECEPTOR AGONISTS PFIZER PRODUCTS INC. (US) 2006-03-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070254318-A1 INHIBITION OF CELL PROLIFERATION RB1, RAF1, NRAS MPL 3220/4885RAB9A 530/4885ALDH1A1 2319/4885
US-20080076771-A1 Thrombopoietin Receptor Agonists MPL, THPO, TBXA2R MPL 1/4885RAB9A 2219/4885ALDH1A1 2423/4885
US-20070265265-A1 N-(5-MEMBERED AROMATIC RING)-AMIDO ANTI-VIRAL COMPOUNDS ZC3HAV1, ZC3HAV1L, HAVCR2 MPL 3886/4885RAB9A 487/4885ALDH1A1 4423/4885
US-20170217923-A1 THERAPEUTIC COMPOUNDS AND RELATED METHODS OF USE PPP4C, PTPRG, PPP2CA MPL 286/4885RAB9A 1231/4885ALDH1A1 2216/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.