Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10317786 | 1.00 | MGLL (0.44) | MGLLRAB9AENPP2ALDH1A1NPC1 | |
| SCHEMBL13029770 | 0.80 | POLB (0.49) | MGLLRAB9AENPP2ALDH1A1NPC1 | |
| SCHEMBL18738533 | 0.80 | POLB (0.49) | MGLLRAB9AENPP2ALDH1A1NPC1 | |
| SCHEMBL2705621 | 0.79 | RAB9A (0.49) | MGLLRAB9ANPC1TP53MAPT | |
| SCHEMBL2705625 | 0.79 | RAB9A (0.49) | MGLLRAB9ANPC1TP53MAPT | |
| SCHEMBL5097623 | 0.77 | LMNA (0.50) | MGLLRAB9AALDH1A1NPC1ATM | |
| SCHEMBL18068762 | 0.77 | SMN1; SMN2 (0.45) | MGLLRAB9AALDH1A1NPC1MAPT | |
| SCHEMBL18068764 | 0.77 | SMN1; SMN2 (0.45) | MGLLRAB9AALDH1A1NPC1MAPT | |
| SCHEMBL18070973 | 0.75 | NPC1 (0.47) | MGLLRAB9AALDH1A1NPC1MAPT | |
| SCHEMBL18070972 | 0.75 | NPC1 (0.47) | MGLLRAB9AALDH1A1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1905773-B1 | Compounds and methods for inhibiting mitotic progression by inhibition of aurora kinase | MILLENNIUM PHARM INC (US) | 2012-07-18 | — | — | EP | disclosed |