Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.38 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL11062962 | 0.89 | TDP1 (0.59) | TDP1TSHROR51E2FFAR3LCK | |
| Propylene Glycol SCHEMBL28327418 | 0.89 | TDP1 (0.59) | TDP1TSHROR51E2FFAR3LCK | |
| Propylene Glycol SCHEMBL49092 | 0.89 | TDP1 (0.67) | TDP1TSHROR51E2FFAR3LCK | |
| Propylene Glycol SCHEMBL21828462 | 0.89 | TDP1 (0.67) | TDP1TSHROR51E2FFAR3LCK | |
| Propylene Glycol SCHEMBL28241687 | 0.89 | TDP1 (0.67) | TDP1TSHROR51E2FFAR3LCK | |
| Propylene Glycol SCHEMBL358822 | 0.89 | TDP1 (0.67) | TDP1TSHROR51E2FFAR3LCK | |
| Propylene Glycol SCHEMBL8850998 | 0.89 | TDP1 (0.67) | TDP1TSHROR51E2FFAR3LCK | |
| Propylene Glycol SCHEMBL36041 | 0.89 | — | — | |
| Propylene Glycol SCHEMBL28867344 | 0.88 | ALDH1A1 (0.50) | TDP1TSHRGPR84FFAR1MAPT | |
| Propylene Glycol SCHEMBL27695057 | 0.86 | TDP1 (0.62) | TDP1TSHROR51E2FFAR3LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8617941-B2 | High-speed graphene transistor and method of fabrication by patternable hard mask materials | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2013-12-31 | — | — | US | disclosed |
| US-20120181506-A1 | High-Speed Graphene Transistor and Method of Fabrication by Patternable Hard Mask Materials | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 2012-07-19 | — | — | US | disclosed |