Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 4/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.56 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | RET | P07949 | 9/20 | 0.38 |
| ▸ | FYN | P06241 | 2/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10380846 | 0.75 | DGAT1 (0.77) | DGAT1KCNH2 | |
| SCHEMBL10381276 | 0.74 | DGAT1 (0.67) | DGAT1KCNH2CNR2 | |
| SCHEMBL10382250 | 0.73 | DGAT1 (0.73) | DGAT1KCNH2 | |
| SCHEMBL10380802 | 0.73 | DGAT1 (0.82) | DGAT1KCNH2 | |
| SCHEMBL10379842 | 0.72 | DGAT1 (0.87) | DGAT1KCNH2 | |
| SCHEMBL25082374 | 0.72 | KCNJ1 (0.44) | DGAT1CNR2 | |
| SCHEMBL10381526 | 0.72 | DGAT1 (0.66) | DGAT1KCNH2 | |
| SCHEMBL10380803 | 0.71 | DGAT1 (0.78) | DGAT1KCNH2 | |
| SCHEMBL16026618 | 0.71 | ME2 (0.48) | — | |
| SCHEMBL360587 | 0.70 | FFAR4 (0.57) | DGAT1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012096813-A1 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-07-19 | — | — | WO | disclosed |
| WO-2012096813-A1 | IMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2012-07-19 | — | — | WO | disclosed |