Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 18/20 | 0.57 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19134108 | 0.81 | FFAR4 (0.65) | FFAR4CYP3A4CYP2C9FFAR1 | |
| SCHEMBL14127679 | 0.80 | DGAT1 (0.61) | DGAT1KCNH2 | |
| SCHEMBL14127680 | 0.80 | DGAT1 (0.61) | DGAT1KCNH2 | |
| SCHEMBL14127751 | 0.80 | DGAT1 (0.61) | DGAT1KCNH2 | |
| SCHEMBL19134107 | 0.80 | FFAR4 (0.61) | FFAR4FFAR1 | |
| SCHEMBL2559241 | 0.77 | CYP2D6 (0.56) | CYP3A4CYP2C9KCNH2 | |
| SCHEMBL20417178 | 0.76 | LMNA (0.52) | DGAT1KCNH2 | |
| SCHEMBL15073173 | 0.76 | DGAT1 (0.57) | FFAR4DGAT1CYP3A4CYP2C9KCNH2 | |
| SCHEMBL15058087 | 0.76 | DGAT1 (0.67) | FFAR4DGAT1CYP3A4CYP2C9KCNH2 | |
| SCHEMBL10146410 | 0.76 | DGAT1 (0.76) | FFAR4DGAT1CYP3A4CYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012009217-A1 | SPIROCYCLIC COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2012-01-19 | — | — | WO | disclosed |