Known targets — ChEMBL curated mechanism
COXFA4COXFA4L2GPD2MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3
The experimentally established mechanism targets of Metformin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metformin SCHEMBL9913821 | 1.00 | — | — | |
| Metformin SCHEMBL20140191 | 0.97 | HTT (0.50) | — | |
| Metformin SCHEMBL20140193 | 0.97 | HTT (0.50) | — | |
| Metformin SCHEMBL20139463 | 0.90 | LMNA (0.41) | — | |
| Metformin SCHEMBL28313216 | 0.90 | LMNA (0.41) | — | |
| Metformin SCHEMBL20141434 | 0.88 | LMNA (0.39) | — | |
| SCHEMBL19038528 | 0.82 | LMNA (0.70) | — | |
| SCHEMBL20865419 | 0.82 | LMNA (0.70) | — | |
| SCHEMBL20315915 | 0.80 | — | — | |
| SCHEMBL19038523 | 0.77 | LMNA (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110167542-A | Nitrite salts of 1, 1-metformin, pharmaceutical compositions and methods of use | 诺沃梅迪科斯有限公司 | 2019-08-23 | — | — | CN | disclosed |
| CN-105308121-A | Resin composition | AJINOMOTO KK | 2016-02-03 | — | — | CN | disclosed |
| CN-104910823-A | Adhesive film | AJINOMOTO KK | 2015-09-16 | — | — | CN | disclosed |
| CN-104045976-A | Resin composition | AJINOMOTO KK | 2014-09-17 | — | — | CN | disclosed |
| EP-2663186-A1 | LIPID-LOWERING ANTIDIABETIC AGENT | Thetis Pharmaceuticals LLC (US) | 2013-11-20 | — | — | EP | disclosed |
| WO-2012097144-A1 | LIPID-LOWERING ANTIDIABETIC AGENT | THETIS PHARMACEUTICALS LLC (US) | 2012-07-19 | — | — | WO | disclosed |