Known targets — ChEMBL curated mechanism
COXFA4COXFA4L2GPD2MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3
The experimentally established mechanism targets of Metformin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metformin SCHEMBL28313216 | 1.00 | LMNA (0.41) | LMNADPP4ADRA1AHTT | |
| Metformin SCHEMBL20141434 | 0.98 | LMNA (0.39) | LMNADPP4ADRA1AHTT | |
| Metformin SCHEMBL9913821 | 0.90 | — | — | |
| Metformin SCHEMBL10325534 | 0.90 | — | — | |
| Metformin SCHEMBL20140191 | 0.87 | HTT (0.50) | LMNADPP4ADRA1AHTT | |
| Metformin SCHEMBL20140193 | 0.87 | HTT (0.50) | LMNADPP4ADRA1AHTT | |
| SCHEMBL20865419 | 0.74 | LMNA (0.70) | LMNADPP4ADRA1AHTT | |
| SCHEMBL19038528 | 0.74 | LMNA (0.70) | LMNADPP4ADRA1AHTT | |
| SCHEMBL20315915 | 0.72 | — | — | |
| SCHEMBL19038523 | 0.69 | LMNA (0.48) | LMNADPP4ADRA1AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018089427-A1 | NITRITE SALTS OF 1, 1-DIMETHYLBIGUANIDE, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE | NOVOMEDIX, LLC (US) | 2018-05-17 | — | — | WO | disclosed |