Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 3/20 | 0.58 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.58 |
| ▸ | TEK | Q02763 | 4/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 10/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | GSK3B | P49841 | 4/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.47 |
| ▸ | CDC7 | O00311 | 4/20 | 0.47 |
| ▸ | PRKACA | P17612 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | CHUK | O15111 | 2/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.47 |
| ▸ | PRKCG | P05129 | 2/20 | 0.47 |
| ▸ | CDK1 | P06493 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL719570 | 0.83 | CCNK (0.71) | CCNKCDK12CYP19A1CDK2CCNE1 | |
| SCHEMBL10464934 | 0.79 | CCNK (0.51) | CCNKCDK12TEKEPHB4CYP19A1 | |
| SCHEMBL2724281 | 0.77 | CCNK (0.62) | CCNKCDK12TEKEPHB4CYP19A1 | |
| SCHEMBL286188 | 0.76 | ALK (0.75) | TEKEPHB4KDR | |
| SCHEMBL10325702 | 0.76 | CCNK (0.49) | CCNKCDK12TEKEPHB4CYP19A1 | |
| SCHEMBL285629 | 0.74 | CCNE1 (0.65) | CCNKCDK12TEKCDK2CCNE1 | |
| SCHEMBL27924063 | 0.74 | KDM4A (0.47) | CCNKCDK12TEKEPHB4CYP19A1 | |
| SCHEMBL10104582 | 0.74 | ALK (0.58) | CCNKCDK12 | |
| SCHEMBL721235 | 0.74 | ALK (0.64) | CCNKCDK12MAPK1 | |
| SCHEMBL20839635 | 0.74 | CCNK (1.00) | CCNKCDK12CYP19A1CDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103403005-B | 5- ([1,2,3] -triazol-4-yl) -7H-pyrrolo [2,3-d ] pyrimidine derivatives | MERCK PATENT GMBH (DE) | 2016-02-03 | — | — | CN | claimed |
| EP-2663566-B1 | 5-([1,2,3]TRIAZOLE-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-03 | — | — | EP | claimed |
| EP-2663566-A1 | 5-([1,2,3]TRIAZOLE-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2013-11-20 | — | — | EP | claimed |
| CN-103403005-A | 5- ([1,2,3] -triazol-4-yl) -7H-pyrrolo [2,3-d ] pyrimidine derivatives | MERCK PATENT GMBH | 2013-11-20 | — | — | CN | claimed |
| WO-2012095142-A1 | 5-([1,2,3]TRIAZOLE-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-07-19 | — | — | WO | claimed |
| CN-103403005-B | 5- ([1,2,3] -triazol-4-yl) -7H-pyrrolo [2,3-d ] pyrimidine derivatives | MERCK PATENT GMBH (DE) | 2016-02-03 | — | — | CN | disclosed |
| US-9079910-B2 | 5-(1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-D]pyrimidine derivatives | MERCK PATENT GMBH (DE) | 2015-07-14 | — | — | US | disclosed |
| US-9079910-B2 | 5-(1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-D]pyrimidine derivatives | MERCK PATENT GMBH (DE) | 2015-07-14 | — | — | US | disclosed |
| US-9079910-B2 | 5-(1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-D]pyrimidine derivatives | MERCK PATENT GMBH (DE) | 2015-07-14 | — | — | US | disclosed |
| EP-2663566-B1 | 5-([1,2,3]TRIAZOLE-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-03 | — | — | EP | disclosed |
| EP-2663566-B1 | 5-([1,2,3]TRIAZOLE-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-03 | — | — | EP | disclosed |
| EP-2663566-A1 | 5-([1,2,3]TRIAZOLE-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2013-11-20 | — | — | EP | disclosed |
| CN-103403005-A | 5- ([1,2,3] -triazol-4-yl) -7H-pyrrolo [2,3-d ] pyrimidine derivatives | MERCK PATENT GMBH | 2013-11-20 | — | — | CN | disclosed |
| US-20130289017-A1 | 5 (1,2,3-TRIAZOL-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-10-31 | — | — | US | disclosed |
| US-20130289017-A1 | 5 (1,2,3-TRIAZOL-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-10-31 | — | — | US | disclosed |
| US-20130289017-A1 | 5 (1,2,3-TRIAZOL-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-10-31 | — | — | US | disclosed |
| WO-2012095142-A1 | 5-([1,2,3]TRIAZOLE-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-07-19 | — | — | WO | disclosed |
| WO-2012095142-A1 | 5-([1,2,3]TRIAZOLE-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130289017-A1 | 5 (1,2,3-TRIAZOL-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | PDK1, PDK2, PDK3 | CCNK 14/4885CDK12 64/4885TEK 2208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.