Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 3/20 | 0.51 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 3/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.44 |
| ▸ | TEK | Q02763 | 2/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | CDC7 | O00311 | 3/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10466551 | 0.83 | CCNK (0.46) | CCNKCDK12KDRPSEN1PSEN2 | |
| SCHEMBL10325990 | 0.79 | CCNK (0.58) | CCNKCDK12KDRCDK2CCNE1 | |
| SCHEMBL10325702 | 0.78 | CCNK (0.49) | CCNKCDK12KDRPSEN1PSEN2 | |
| SCHEMBL719570 | 0.77 | CCNK (0.71) | CCNKCDK12KDRCDK2CCNE1 | |
| SCHEMBL719125 | 0.76 | CCNK (0.57) | CCNKCDK12KDRPSEN1PSEN2 | |
| SCHEMBL2724281 | 0.73 | CCNK (0.62) | CCNKCDK12KDRCDK2CCNE1 | |
| SCHEMBL10325553 | 0.73 | CDC7 (0.48) | CCNKCDK12KDRPSEN1PSEN2 | |
| SCHEMBL286188 | 0.72 | ALK (0.75) | KDREPHB4TEK | |
| SCHEMBL10104582 | 0.70 | ALK (0.58) | CCNKCDK12 | |
| SCHEMBL2733285 | 0.70 | MAPK1 (0.59) | CCNKCDK12KDREPHB4TEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9079910-B2 | 5-(1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-D]pyrimidine derivatives | MERCK PATENT GMBH (DE) | 2015-07-14 | — | — | US | claimed |
| EP-2663566-B1 | 5-([1,2,3]TRIAZOLE-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-03 | — | — | EP | claimed |
| US-20130289017-A1 | 5 (1,2,3-TRIAZOL-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-10-31 | — | — | US | claimed |
| US-9079910-B2 | 5-(1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-D]pyrimidine derivatives | MERCK PATENT GMBH (DE) | 2015-07-14 | — | — | US | disclosed |
| US-9079910-B2 | 5-(1,2,3-triazol-4-yl)-7H-pyrrolo[2,3-D]pyrimidine derivatives | MERCK PATENT GMBH (DE) | 2015-07-14 | — | — | US | disclosed |
| EP-2663566-B1 | 5-([1,2,3]TRIAZOLE-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-03 | — | — | EP | disclosed |
| EP-2663566-B1 | 5-([1,2,3]TRIAZOLE-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-03 | — | — | EP | disclosed |
| US-20130289017-A1 | 5 (1,2,3-TRIAZOL-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-10-31 | — | — | US | disclosed |
| US-20130289017-A1 | 5 (1,2,3-TRIAZOL-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-10-31 | — | — | US | disclosed |
| WO-2012095142-A1 | 5-([1,2,3]TRIAZOLE-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-07-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130289017-A1 | 5 (1,2,3-TRIAZOL-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | PDK1, PDK2, PDK3 | CCNK 14/4885CDK12 64/4885KDR 779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.