Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
| ▸ | RAF1 | P04049 | 6/20 | 0.47 |
| ▸ | BRAF | P15056 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | IDH2 | P48735 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL965836 | 0.92 | AKT1 (0.50) | AKT1RAF1BRAFLMNAKMT2A | |
| SCHEMBL10327354 | 0.87 | AKT1 (0.52) | AKT1RAF1BRAFLMNAKMT2A | |
| SCHEMBL965838 | 0.85 | AKT1 (0.46) | AKT1RAF1BRAFLMNAKMT2A | |
| SCHEMBL3459645 | 0.73 | AKT1 (0.60) | AKT1RAF1BRAFLMNAKMT2A | |
| SCHEMBL967985 | 0.70 | MAPT (0.46) | LMNAKMT2AMAPTGAAMEN1 | |
| SCHEMBL3459651 | 0.70 | AKT1 (0.56) | AKT1RAF1BRAFLMNAKMT2A | |
| SCHEMBL5208545 | 0.69 | LMNA (0.63) | AKT1LMNAKMT2AMAPTGAA | |
| SCHEMBL12947024 | 0.68 | LCK (0.50) | LMNAKMT2AMAPTGAAMEN1 | |
| SCHEMBL29671886 | 0.68 | AKT1 (0.55) | AKT1RAF1BRAFLMNAKMT2A | |
| SCHEMBL28755083 | 0.68 | AKT1 (0.55) | AKT1RAF1BRAFLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | disclosed |