Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 7/20 | 0.49 |
| ▸ | BRAF | P15056 | 7/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28755083 | 1.00 | AKT1 (0.55) | AKT1MAPTSMN1; SMN2HTTNPSR1 | |
| SCHEMBL28755086 | 0.93 | MAPT (0.56) | AKT1MAPTSMN1; SMN2HTTNPSR1 | |
| SCHEMBL29671926 | 0.93 | MAPT (0.56) | AKT1MAPTSMN1; SMN2HTTNPSR1 | |
| SCHEMBL29671962 | 0.91 | LMNA (0.51) | AKT1MAPTSMN1; SMN2KMT2ALMNA | |
| SCHEMBL28755175 | 0.91 | LMNA (0.51) | AKT1MAPTSMN1; SMN2KMT2ALMNA | |
| SCHEMBL28755219 | 0.89 | PIK3CB (0.54) | AKT1MAPTSMN1; SMN2KMT2APIK3CD | |
| SCHEMBL29671929 | 0.89 | PIK3CB (0.54) | AKT1MAPTSMN1; SMN2KMT2APIK3CD | |
| SCHEMBL29671952 | 0.85 | PIK3CD (0.57) | AKT1MAPTNPSR1LMNAPIK3CD | |
| SCHEMBL28755300 | 0.85 | PIK3CD (0.57) | AKT1MAPTNPSR1LMNAPIK3CD | |
| SCHEMBL29671991 | 0.84 | PIK3CD (0.48) | AKT1MAPTKMT2APIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114573582-B | 1,2,3, 4-tetrahydropyrido [2,3-d ] pyrimidine compound and preparation method and application thereof | 沈阳药科大学 | 2023-06-16 | — | — | CN | claimed |
| CN-114573582-A | 1,2,3, 4-tetrahydropyrido [2,3-d ] pyrimidine compound and preparation method and application thereof | 沈阳药科大学 | 2022-06-03 | — | — | CN | claimed |
| CN-114573582-B | 1,2,3, 4-tetrahydropyrido [2,3-d ] pyrimidine compound and preparation method and application thereof | 沈阳药科大学 | 2023-06-16 | — | — | CN | disclosed |
| CN-114573582-A | 1,2,3, 4-tetrahydropyrido [2,3-d ] pyrimidine compound and preparation method and application thereof | 沈阳药科大学 | 2022-06-03 | — | — | CN | disclosed |