Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10327382 | 0.91 | SMN1; SMN2 (0.46) | SMN1; SMN2MEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL10327240 | 0.91 | SMN1; SMN2 (0.46) | SMN1; SMN2MEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL964525 | 0.89 | SMN1; SMN2 (0.47) | SMN1; SMN2MEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL12915786 | 0.89 | SMN1; SMN2 (0.47) | SMN1; SMN2MEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL10327509 | 0.81 | SMN1; SMN2 (0.43) | SMN1; SMN2MEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL10327048 | 0.80 | SMN1; SMN2 (0.55) | SMN1; SMN2MEN1KMT2AALDH1A1POLB | |
| SCHEMBL10327476 | 0.80 | SMN1; SMN2 (0.45) | SMN1; SMN2MEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL10327151 | 0.80 | LMNA (0.45) | SMN1; SMN2MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL964349 | 0.79 | KMT2A (0.49) | SMN1; SMN2MEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL963698 | 0.79 | KMT2A (0.49) | SMN1; SMN2MEN1KMT2AALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | disclosed |