Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | XBP1 | P17861 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL968560 | 0.90 | SMN1; SMN2 (0.52) | SMN1; SMN2MEN1KMT2AMAPTGAA | |
| SCHEMBL965888 | 0.89 | SMN1; SMN2 (0.51) | SMN1; SMN2MEN1KMT2AMAPTGAA | |
| SCHEMBL967015 | 0.88 | KMT2A (0.56) | SMN1; SMN2MEN1KMT2AMAPTGAA | |
| SCHEMBL966931 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2MEN1KMT2AMAPTGAA | |
| SCHEMBL10327382 | 0.82 | SMN1; SMN2 (0.46) | SMN1; SMN2MEN1KMT2AMAPTGAA | |
| SCHEMBL10327240 | 0.82 | SMN1; SMN2 (0.46) | SMN1; SMN2MEN1KMT2AMAPTGAA | |
| SCHEMBL10327506 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2MEN1KMT2AMAPTGAA | |
| SCHEMBL969360 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2MEN1KMT2AMAPTGAA | |
| SCHEMBL10327353 | 0.80 | SMN1; SMN2 (0.41) | SMN1; SMN2MEN1KMT2AMAPTGAA | |
| SCHEMBL10327151 | 0.80 | LMNA (0.45) | SMN1; SMN2MEN1KMT2AMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | disclosed |