Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL964852 | 0.89 | SMN1; SMN2 (0.47) | LMNASMN1; SMN2TP53FAAHTRPV1 | |
| SCHEMBL10327119 | 0.80 | LMNA (0.48) | LMNASMN1; SMN2TP53FAAHTRPV1 | |
| SCHEMBL10327048 | 0.80 | SMN1; SMN2 (0.55) | LMNASMN1; SMN2TP53ALDH1A1MAPT | |
| SCHEMBL10327353 | 0.80 | SMN1; SMN2 (0.41) | LMNASMN1; SMN2TP53ALDH1A1MAPT | |
| SCHEMBL10327240 | 0.79 | SMN1; SMN2 (0.46) | LMNASMN1; SMN2TP53ALDH1A1MAPT | |
| SCHEMBL10327382 | 0.79 | SMN1; SMN2 (0.46) | LMNASMN1; SMN2TP53ALDH1A1MAPT | |
| SCHEMBL10327490 | 0.74 | ALDH1A1 (0.53) | LMNASMN1; SMN2ALDH1A1MAPTCDK8 | |
| SCHEMBL966091 | 0.73 | KMT2A (0.48) | LMNASMN1; SMN2TP53FAAHTRPV1 | |
| SCHEMBL10327338 | 0.73 | ALDH1A1 (0.43) | LMNASMN1; SMN2TP53ALDH1A1MAPT | |
| SCHEMBL10327506 | 0.73 | SMN1; SMN2 (0.47) | LMNASMN1; SMN2ALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678168-B1 | P70S6 KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2012-07-11 | — | — | EP | disclosed |