SCHEMBL1032791

SCHEMBL1032791

CCCNCCOc1ccc(NS(=O)(=O)c2ccc(OCCF)cc2)c(OC)n1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.44
HTT P42858 4/20 0.44
LMNA P02545 4/20 0.44
SMN1; SMN2 Q16637 4/20 0.44
PKM P14618 2/20 0.39
SQSTM1 Q13501 2/20 0.39
KEAP1 Q14145 2/20 0.39
NFE2L2 Q16236 2/20 0.39
MAPT P10636 3/20 0.39
KMT2A Q03164 2/20 0.39
KDM4E B2RXH2 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
TRIM24 O15164 1/20 0.38
BRPF1 P55201 1/20 0.38
F2 P00734 1/20 0.38
F10 P00742 1/20 0.38
PRSS1 P07477 1/20 0.38
PRSS2 P07478 1/20 0.38
PRSS3 P35030 1/20 0.38
ST14 Q9Y5Y6 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4245486 0.99 TSHR (0.44) TSHRHTTLMNASMN1; SMN2PKM
SCHEMBL1030310 0.89 TSHR (0.41) TSHRHTTLMNASMN1; SMN2PKM
SCHEMBL1032412 0.89 LMNA (0.41) TSHRHTTLMNASMN1; SMN2PKM
SCHEMBL1028966 0.89 CYP3A4 (0.39) TSHRHTTLMNASMN1; SMN2PKM
SCHEMBL1033689 0.88 PKM (0.43) TSHRHTTLMNASMN1; SMN2PKM
Hydrochloric Acid SCHEMBL4246986 0.88 TSHR (0.40) TSHRHTTLMNASMN1; SMN2PKM
Hydrochloric Acid SCHEMBL4250607 0.88 LMNA (0.40) TSHRHTTLMNASMN1; SMN2PKM
SCHEMBL1031476 0.88 FFAR4 (0.40) TSHRHTTLMNASMN1; SMN2SQSTM1
SCHEMBL1032629 0.88 LMNA (0.39) TSHRHTTLMNASMN1; SMN2PKM
Hydrochloric Acid SCHEMBL4244073 0.88 CYP3A4 (0.39) TSHRHTTLMNASMN1; SMN2PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2013179-B1 ARYLOXYETHYLAMINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR ABBOTT GMBH & CO KG (DE) 2011-01-19 EP disclosed
EP-2013179-A1 ARYLOXYETHYLAMINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR Abbott GmbH & Co. KG (DE) 2009-01-14 EP disclosed
WO-2007118859-A1 ARYLOXYETHYLAMINE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR ABBOTT GMBH & CO. KG (DE) 2007-10-25 WO disclosed