Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 19/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 11/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23331997 | 0.77 | ADORA1 (0.42) | GRM1KDM4EHTTALDH1A1HPGD | |
| SCHEMBL24616830 | 0.76 | ALDH1A1 (0.35) | KDM4EALDH1A1 | |
| SCHEMBL13563775 | 0.75 | ACVR1 (0.40) | GRM1KMT2A | |
| SCHEMBL10328322 | 0.75 | GRM1 (0.39) | GRM1KDM4EHTTALDH1A1HPGD | |
| SCHEMBL8237325 | 0.74 | ROCK2 (0.40) | GRM1KDM4EHTTALDH1A1HPGD | |
| SCHEMBL8242718 | 0.74 | GRM1 (0.69) | GRM1KDM4EHTTALDH1A1HPGD | |
| SCHEMBL10328337 | 0.67 | ACVR1 (0.50) | KDM4EALDH1A1KMT2A | |
| SCHEMBL14438644 | 0.66 | ADORA2A (0.48) | HSD17B10 | |
| SCHEMBL23697044 | 0.66 | SMPD3 (0.34) | GRM1KDM4EHTTALDH1A1HPGD | |
| SCHEMBL25098010 | 0.66 | SMPD3 (0.34) | GRM1KDM4EHTTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217169-B2 | Coupling agents for peptide synthesis | UNIVERSITY OF MASSACHUSETTS (US) | 2012-07-10 | — | — | US | disclosed |
| US-20110028720-A1 | New Coupling Agents for Peptide Synthesis | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-02-03 | — | — | US | disclosed |
| US-7812158-B2 | Coupling agents for peptide synthesis | UNIVERSITY OF MASSACHUSETTS (US) | 2010-10-12 | — | — | US | disclosed |
| US-20070112196-A1 | New coupling agents for peptide synthesis | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112196-A1 | New coupling agents for peptide synthesis | NGLY1, NPPA, VIP | GRM1 3275/4885KDM4E 4768/4885HTT 2761/4885 |
| US-20110028720-A1 | New Coupling Agents for Peptide Synthesis | NGLY1, NPPA, VIP | GRM1 3368/4885KDM4E 4645/4885HTT 2620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.