SCHEMBL1032857

SCHEMBL1032857

Ic1ccc(-c2cc(I)ccc2-c2ccccc2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 1/20 0.41
ALOX5 P09917 1/20 0.40
PTGS2 P35354 4/20 0.37
ESR2 Q92731 2/20 0.36
MEN1 O00255 1/20 0.36
APAF1 O14727 1/20 0.36
NPC1 O15118 1/20 0.36
LMNA P02545 1/20 0.36
MAPT P10636 1/20 0.36
THRB P10828 1/20 0.36
XBP1 P17861 1/20 0.36
PTBP1 P26599 1/20 0.36
HTT P42858 1/20 0.36
RAB9A P51151 1/20 0.36
GALK1 P51570 1/20 0.36
BLM P54132 1/20 0.36
SMAD3 P84022 1/20 0.36
KMT2A Q03164 1/20 0.36
ATM Q13315 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6307069 1.00 BACE1 (0.41) BACE1ALOX5PTGS2ESR2MEN1
SCHEMBL13445421 0.95 BACE1 (0.44) BACE1ALOX5PTGS2ESR2ALDH1A1
SCHEMBL22815354 0.88 HPRT1 (0.44) ESR2MEN1NPC1LMNAMAPT
SCHEMBL24658103 0.88 HPRT1 (0.44) ESR2MEN1NPC1LMNAMAPT
SCHEMBL6307073 0.87 PDE4A (0.38) BACE1ALOX5ESR2LMNAMAPT
SCHEMBL24658105 0.87 PDE4A (0.38) BACE1ALOX5ESR2LMNAMAPT
SCHEMBL19658348 0.85 PTGS2 (0.46) BACE1PTGS2ALDH1A1HSD17B10HPGD
SCHEMBL30913227 0.85 PTGS2 (0.46) BACE1PTGS2ALDH1A1HSD17B10HPGD
SCHEMBL24656817 0.84 HDAC7 (0.44) ESR2MEN1NPC1LMNAMAPT
SCHEMBL24882501 0.83 PTGS2 (0.45) BACE1PTGS2MEN1APAF1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4714779-A Aromatic aryl amine polymers XEROX CORPORATION (US) 1987-12-22 US claimed
EP-0052961-B1 AMINE POLYMERS AND IMAGING MEMBERS CONTAINING AMINE POLYMERS XEROX CORPORATION (US) 1985-09-11 EP claimed
EP-0052961-A1 Amine polymers and imaging members containing amine polymers XEROX CORPORATION (US) 1982-06-02 EP claimed
US-8951443-B2 Organic semiconducting material and electronic component NOVALED AG (DE) 2015-02-10 US disclosed
US-20130193414-A1 Organic Semiconducting Material and Electronic Component SENSIENT IMAGING TECHNOLOGIES GMBH (DE) 2013-08-01 US disclosed
WO-2011134458-A1 ORGANIC SEMICONDUCTING MATERIAL AND ELECTRONIC COMPONENT NOVALED AG (DE) 2011-11-03 WO disclosed
EP-1850185-B1 Imaging member, method of imaging using it and method of making said imaging member XEROX CORP (US) 2011-01-19 EP disclosed
US-7514191-B2 Imaging member XEROX CORPORATION (US) 2009-04-07 US disclosed
US-20070254226-A1 Imaging member XEROX CORPORATION 2007-11-01 US disclosed
US-20070254223-A1 IMAGING MEMBER XEROX CORPORATION 2007-11-01 US disclosed
EP-1850185-A2 Imaging Member Xerox Corporation (US) 2007-10-31 EP disclosed
EP-0052961-B1 AMINE POLYMERS AND IMAGING MEMBERS CONTAINING AMINE POLYMERS XEROX CORPORATION (US) 1985-09-11 EP disclosed
EP-0034425-B1 PROCESS FOR PREPARING ARYLAMINES XEROX CORPORATION (US) 1984-05-16 EP disclosed
EP-0028888-B1 PROCESS FOR PRODUCING A DIIODINATED POLYARYLIDENE COMPOUND XEROX CORPORATION (US) 1984-04-25 EP disclosed
EP-0029703-B1 ELECTROPHOTOGRAPHIC IMAGING MEMBER XEROX CORPORATION (US) 1984-03-21 EP disclosed
EP-0052961-A1 Amine polymers and imaging members containing amine polymers XEROX CORPORATION (US) 1982-06-02 EP disclosed
EP-0034425-A2 Process for preparing arylamines XEROX CORPORATION (US) 1981-08-26 EP disclosed
US-4273846-A Imaging member having a charge transport layer of a terphenyl diamine and a polycarbonate resin XEROX CORPORATION (US) 1981-06-16 US disclosed
EP-0028888-A1 Process for producing a diiodinated polyarylidene compound XEROX CORPORATION (US) 1981-05-20 EP disclosed
US-4240987-A Chemical process XEROX CORPORATION (US) 1980-12-23 US disclosed