Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | PDE5A | O76074 | 2/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10328642 | 0.92 | PTGER4 (0.37) | PTGER4KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL6900481 | 0.83 | MEN1 (0.42) | PTGER4KMT2AMEN1GPR35TDP1 | |
| SCHEMBL10328605 | 0.82 | MEN1 (0.48) | KMT2AMEN1TDP1ELANE | |
| SCHEMBL10328548 | 0.81 | MEN1 (0.50) | KMT2AMEN1TDP1ELANE | |
| SCHEMBL10494168 | 0.81 | MEN1 (0.50) | KMT2AMEN1TDP1ELANE | |
| SCHEMBL13323728 | 0.80 | ALDH1A1 (0.38) | PTGER4KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL10328645 | 0.78 | LMNA (0.43) | PTGER4RAB9ANPC1CYP1A2CYP2C19 | |
| SCHEMBL1037140 | 0.77 | PTGER4 (0.52) | PTGER4KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL10328599 | 0.77 | GAA (0.44) | PTGER4KMT2AMEN1RAB9ANPC1 | |
| SCHEMBL10328594 | 0.77 | MEN1 (0.50) | PTGER4KMT2AMEN1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120923-B1 | USE OF SUBSTITUTED PYRANONE ACID DERIVATIVES FOR THE TREATMENT OF METABOLIC SYNDROME | SANOFI SA (FR) | 2012-07-18 | — | — | EP | disclosed |