SCHEMBL1033023

SCHEMBL1033023

CC(=O)NC[C@H]1CN(c2ccc(I)c(F)c2)C(=O)O1

nearest known ligand 0.70

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
MAOA P21397 6/20 0.70
MAOB P27338 4/20 0.70
PTGS1 P23219 2/20 0.70
SDHA P31040 2/20 0.70
LMNA P02545 1/20 0.70
CALML3 P27482 1/20 0.70
F10 P00742 4/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1033024 1.00 MAOA (0.70) MAOAMAOBPTGS1SDHALMNA
SCHEMBL16701350 0.90 MAOA (0.74) MAOAMAOBPTGS1SDHALMNA
SCHEMBL16701349 0.90 MAOA (0.74) MAOAMAOBPTGS1SDHALMNA
SCHEMBL5917645 0.89 MAOA (0.56) MAOAMAOBPTGS1SDHALMNA
SCHEMBL12950996 0.89 MAOA (0.72) MAOAMAOBPTGS1SDHALMNA
SCHEMBL6097822 0.89 MAOA (0.72) MAOAMAOBPTGS1SDHALMNA
SCHEMBL3328443 0.89 MAOA (0.76) MAOAMAOBPTGS1SDHALMNA
SCHEMBL3328441 0.89 MAOA (0.76) MAOAMAOBPTGS1SDHALMNA
SCHEMBL13034192 0.89 MAOA (0.72) MAOAMAOBPTGS1SDHALMNA
SCHEMBL2088204 0.88 MAOA (0.71) MAOAMAOBPTGS1SDHALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 169 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118164975-B Quaternary ammonium salt oxazolidinone derivative and pharmaceutically acceptable salt thereof, preparation method and application 中国医学科学院医药生物技术研究所 2024-08-09 CN disclosed
CN-118164975-A Quaternary ammonium salt oxazolidinone derivative and pharmaceutically acceptable salt thereof, preparation method and application 中国医学科学院医药生物技术研究所 2024-06-11 CN disclosed
EP-3442526-B1 TOPICAL FORMULATIONS OF BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF MELINTA SUBSIDIARY CORP (US) 2023-01-04 EP disclosed
CN-108976222-B Heterocyclic ring-containing biaryl oxazolidinone compound and preparation method thereof 沈阳药科大学 2021-09-03 CN disclosed
US-10471046-B2 Method for treating, preventing, or reducing the risk of skin infection MELINTA SUBSIDARY CORP. (US) 2019-11-12 US disclosed
EP-3442526-A1 TOPICAL FORMULATIONS OF BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF Melinta Subsidiary Corp. (US) 2019-02-20 EP disclosed
WO-2017200979-A1 TOPICAL FORMULATIONS OF BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF MELINTA THERAPEUTICS, INC. (US) 2017-11-23 WO disclosed
US-20170333400-A1 TOPICAL FORMULATIONS OF BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF MELINTA SUBSIDIARY CORP. 2017-11-23 US disclosed
US-20170333400-A1 TOPICAL FORMULATIONS OF BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF MELINTA SUBSIDIARY CORP. 2017-11-23 US disclosed
US-20170333400-A1 TOPICAL FORMULATIONS OF BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF MELINTA SUBSIDIARY CORP. 2017-11-23 US disclosed
EP-0856002-A1 PHENYLOXAZOLIDINONES HAVING A C-C BOND TO 4-8 MEMBERED HETEROCYCLIC RINGS PHARMACIA & UPJOHN COMPANY (US) 1998-08-05 EP disclosed
EP-0673370-B1 TROPONE-SUBSTITUTED PHENYLOXAZOLIDINONE ANTIBACTERIAL AGENTS UPJOHN CO (US) 1998-01-07 EP disclosed
US-5654428-A BACTERICIDES PHARMACIA & UPJOHN COMPANY (US) 1997-08-05 US disclosed
WO-1997009328-A1 PHENYLOXAZOLIDINONES HAVING A C-C BOND TO 4-8 MEMBERED HETEROCYCLIC RINGS PHARMACIA & UPJOHN COMPANY (US) 1997-03-13 WO disclosed
EP-0610265-B1 SUBSTITUTED ARYL- AND HETEROARYLPHENYLOXAZOLIDINONES USEFUL AS ANTIBACTERIAL AGENTS UPJOHN CO (US) 1996-12-27 EP disclosed
US-5523403-A Tropone-substituted phenyloxazolidinone antibacterial agents THE UPJOHN COMPANY (US) 1996-06-04 US disclosed
EP-0673370-A1 TROPONE-SUBSTITUTED PHENYLOXAZOLIDINONE ANTIBACTERIAL AGENTS PHARMACIA & UPJOHN COMPANY (US) 1995-09-27 EP disclosed
EP-0610265-A1 SUBSTITUTED ARYL- AND HETEROARYLPHENYLOXAZOLIDINONES USEFUL AS ANTIBACTERIAL AGENTS. UPJOHN CO (US) 1994-08-17 EP disclosed
WO-1994013649-A1 TROPONE-SUBSTITUTED PHENYLOXAZOLIDINONE ANTIBACTERIAL AGENTS THE UPJOHN COMPANY (US) 1994-06-23 WO disclosed
WO-1993009103-A1 SUBSTITUTED ARYL- AND HETEROARYLPHENYLOXAZOLIDINONES USEFUL AS ANTIBACTERIAL AGENTS THE UPJOHN COMPANY (US) 1993-05-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170333400-A1 TOPICAL FORMULATIONS OF BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF CUTA, CYP19A1, KAT2A MAOA 379/4885MAOB 219/4885PTGS1 2113/4885
US-10471046-B2 Method for treating, preventing, or reducing the risk of skin infection CUTA, CYP17A1, HSD17B11 MAOA 1569/4885MAOB 1093/4885PTGS1 695/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.