Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | NR2F2 | P24468 | 4/20 | 0.45 |
| ▸ | STAT3 | P40763 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | PEAK1 | Q9H792 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1027235 | 0.86 | HRH1 (0.47) | ALDH1A1HRH1NR2F2STAT3HTT | |
| SCHEMBL14276917 | 0.73 | HTT (0.63) | ALDH1A1HRH1NR2F2STAT3HTT | |
| SCHEMBL28322311 | 0.73 | MEN1 (0.64) | ALDH1A1HRH1NR2F2STAT3HTT | |
| SCHEMBL12789895 | 0.70 | MEN1 (0.71) | ALDH1A1HRH1NR2F2STAT3HTT | |
| SCHEMBL1032819 | 0.70 | TSHR (0.59) | ALDH1A1HTTLMNAMAPTNPSR1 | |
| SCHEMBL17080821 | 0.70 | KIT (0.56) | ALDH1A1HRH1NR2F2STAT3HTT | |
| SCHEMBL1030972 | 0.68 | L3MBTL3 (0.49) | ALDH1A1HPGD | |
| SCHEMBL1031186 | 0.68 | STAT3 (0.46) | ALDH1A1HRH1NR2F2STAT3HTT | |
| SCHEMBL1031602 | 0.67 | L3MBTL3 (0.54) | ALDH1A1MEN1 | |
| SCHEMBL29520086 | 0.66 | MAPT (0.80) | ALDH1A1HRH1NR2F2STAT3HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |