Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1029076 | 0.84 | TSHR (0.55) | TSHRHTTSMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL1028175 | 0.75 | TP53 (0.52) | TSHRHTTSMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL1030117 | 0.75 | TSHR (0.57) | TSHRHTTSMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL19420480 | 0.75 | ALDH1A1 (0.78) | TSHRHTTSMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL1030972 | 0.73 | L3MBTL3 (0.49) | ALDH1A1KMT2A | |
| SCHEMBL1031602 | 0.72 | L3MBTL3 (0.54) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL17229219 | 0.71 | ALDH1A1 (0.75) | TSHRHTTSMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL1034078 | 0.71 | MAPT (0.46) | TSHRHTTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9321484 | 0.70 | SMN1; SMN2 (0.68) | TSHRHTTSMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL94576 | 0.70 | SMN1; SMN2 (0.68) | TSHRHTTSMN1; SMN2ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |