Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | TEK | Q02763 | 2/20 | 0.41 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2886002 | 0.90 | EPHB4 (0.53) | EPHB4KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL2882553 | 0.89 | EPHB4 (0.52) | EPHB4SMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL5611473 | 0.77 | KDR (0.48) | EPHB4SMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL5592906 | 0.76 | KMT2A (0.50) | EPHB4KMT2AMEN1LMNAMAPT | |
| SCHEMBL5585843 | 0.76 | EPHB4 (0.52) | EPHB4SMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL5586080 | 0.75 | EPHB4 (0.46) | EPHB4SMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL5636353 | 0.75 | KDR (0.46) | EPHB4SMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL5669188 | 0.75 | GPR142 (0.47) | EPHB4SMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL5611381 | 0.75 | EPHB4 (0.45) | EPHB4SMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL5593089 | 0.74 | EPHB4 (0.54) | EPHB4KMT2AMEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8222421-B2 | Certain substituted ureas, as modulators of kinase activity | GILEAD CONNECTICUT, INC. (US) | 2012-07-17 | — | — | US | disclosed |
| US-20100286190-A1 | CERTAIN SUBSTITUTED UREAS, AS MODULATORS OF KINASE ACTIVITY | CGI PHARMACEUTICALS, INC. | 2010-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286190-A1 | CERTAIN SUBSTITUTED UREAS, AS MODULATORS OF KINASE ACTIVITY | UCK2, CHUK, TK1 | EPHB4 2792/4885SMN1; SMN2 4446/4885KMT2A 3039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.