Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | RAB9A | P51151 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | RHEB | Q15382 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.49 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.46 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.46 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.44 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10333346 | 0.86 | ALDH1A1 (0.47) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL10333235 | 0.81 | KDM4E (0.64) | NPC1RAB9AALDH1A1KDM4EGPR55 | |
| SCHEMBL15876215 | 0.79 | NPC1 (0.62) | NPC1RAB9AMEN1KMT2ARHEB | |
| SCHEMBL22955432 | 0.78 | NPC1 (0.61) | NPC1RAB9AMEN1KMT2ARHEB | |
| SCHEMBL10736050 | 0.78 | KDM4E (0.46) | NPC1RAB9AALDH1A1KDM4EGPR55 | |
| SCHEMBL7270979 | 0.75 | ALOX5 (0.51) | NPC1RAB9AALDH1A1KDM4EGPR55 | |
| SCHEMBL10768962 | 0.75 | HDAC6 (0.63) | NPBWR1 | |
| SCHEMBL10768955 | 0.75 | HDAC6 (0.50) | NPC1RAB9AALDH1A1KDM4ENPSR1 | |
| SCHEMBL3090064 | 0.75 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2ARHEB | |
| SCHEMBL9000174 | 0.74 | RHEB (0.73) | NPC1RAB9AMEN1KMT2ARHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4900751-A | 2-Pyridinyl-phenyl-sulphinyl-and-phenyl-thio-benzimidazoles having antiflammatory or gastic acid secretion inhibition activity | FISONS PLC (GB) | 1990-02-13 | — | — | US | disclosed |
| EP-0283504-A1 | COMPOUNDS | FISONS plc (GB) | 1988-09-28 | — | — | EP | disclosed |
| WO-1988002367-A1 | COMPOUNDS | FISONS PLC (GB) | 1988-04-07 | — | — | WO | disclosed |
| EP-0262845-A1 | Heterocyclic substituted azole derivatives | FISONS plc (GB) | 1988-04-06 | — | — | EP | disclosed |