Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | NPC1 | O15118 | 8/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.47 |
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | AMY1A | P0DUB6 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10333320 | 0.86 | NPC1 (0.59) | ALDH1A1NPC1KDM4ERAB9AGPR55 | |
| SCHEMBL10333235 | 0.82 | KDM4E (0.64) | ALDH1A1NPC1KDM4ERAB9AGPR55 | |
| SCHEMBL11528753 | 0.81 | NPC1 (0.67) | ALDH1A1NPC1KDM4ERAB9AGPR55 | |
| SCHEMBL13405888 | 0.81 | ALDH1A1 (0.71) | ALDH1A1NPC1KDM4ERAB9AGPR55 | |
| SCHEMBL3336164 | 0.78 | ALDH1A1 (0.67) | ALDH1A1NPC1KDM4ERAB9AGPR55 | |
| SCHEMBL10041675 | 0.78 | NPC1 (0.62) | ALDH1A1NPC1KDM4ERAB9AGPR55 | |
| SCHEMBL22956044 | 0.78 | KDM4E (0.59) | ALDH1A1NPC1KDM4ERAB9AGPR55 | |
| SCHEMBL7393988 | 0.78 | F7 (0.55) | ALDH1A1NPC1KDM4ERAB9AGPR55 | |
| SCHEMBL10768955 | 0.78 | HDAC6 (0.50) | ALDH1A1NPC1KDM4ERAB9ANPSR1 | |
| SCHEMBL23758274 | 0.78 | AMY1A (0.64) | AMY1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4900751-A | 2-Pyridinyl-phenyl-sulphinyl-and-phenyl-thio-benzimidazoles having antiflammatory or gastic acid secretion inhibition activity | FISONS PLC (GB) | 1990-02-13 | — | — | US | disclosed |
| EP-0283504-A1 | COMPOUNDS | FISONS plc (GB) | 1988-09-28 | — | — | EP | disclosed |
| US-4767773-A | BENZOYL UREAS AND BENZOFURANYL CARBAMATE COMPONENTS | RHONE-POULENC NEDERLAND B.V. (NL) | 1988-08-30 | — | — | US | disclosed |
| WO-1988002367-A1 | COMPOUNDS | FISONS PLC (GB) | 1988-04-07 | — | — | WO | disclosed |
| EP-0262845-A1 | Heterocyclic substituted azole derivatives | FISONS plc (GB) | 1988-04-06 | — | — | EP | disclosed |