Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 3/20 | 0.44 |
| ▸ | NOS3 | P29474 | 2/20 | 0.44 |
| ▸ | NOS1 | P29475 | 2/20 | 0.44 |
| ▸ | CYP2E1 | P05181 | 7/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 7/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 7/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | CBFB | Q13951 | 2/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | CCR8 | P51685 | 1/20 | 0.40 |
| ▸ | BRS3 | P32247 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10333572 | 0.89 | NOS2 (0.48) | NOS2NOS3NOS1CYP2E1CYP2C8 | |
| SCHEMBL10334040 | 0.88 | NOS2 (0.57) | NOS2NOS3NOS1CYP2E1CYP2C8 | |
| SCHEMBL10333243 | 0.86 | NOS2 (0.46) | NOS2NOS3NOS1CYP2E1CYP2C8 | |
| SCHEMBL10333395 | 0.85 | NOS2 (0.45) | NOS2NOS3NOS1CYP2E1CYP2C8 | |
| SCHEMBL10333633 | 0.84 | NPC1 (0.50) | NOS2NOS3NOS1CYP2E1CYP2C8 | |
| SCHEMBL10333076 | 0.84 | ALDH1A1 (0.48) | NOS2NOS3NOS1CYP2D6CYP2C9 | |
| SCHEMBL10334188 | 0.82 | PRMT5 (0.47) | NOS2NOS3NOS1CYP2E1CYP2C8 | |
| SCHEMBL10333582 | 0.82 | NOS2 (0.43) | NOS2NOS3NOS1CYP2E1CYP2C8 | |
| SCHEMBL10333151 | 0.81 | SENP1 (0.43) | NOS2NOS3NOS1CYP2D6CYP2C9 | |
| SCHEMBL10333695 | 0.81 | PDE10A (0.47) | NOS2NOS3NOS1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0283504-A1 | COMPOUNDS | FISONS plc (GB) | 1988-09-28 | — | — | EP | claimed |
| WO-1988002367-A1 | COMPOUNDS | FISONS PLC (GB) | 1988-04-07 | — | — | WO | claimed |
| EP-0262845-A1 | Heterocyclic substituted azole derivatives | FISONS plc (GB) | 1988-04-06 | — | — | EP | claimed |
| US-4900751-A | 2-Pyridinyl-phenyl-sulphinyl-and-phenyl-thio-benzimidazoles having antiflammatory or gastic acid secretion inhibition activity | FISONS PLC (GB) | 1990-02-13 | — | — | US | disclosed |
| EP-0283504-A1 | COMPOUNDS | FISONS plc (GB) | 1988-09-28 | — | — | EP | disclosed |
| WO-1988002367-A1 | COMPOUNDS | FISONS PLC (GB) | 1988-04-07 | — | — | WO | disclosed |
| EP-0262845-A1 | Heterocyclic substituted azole derivatives | FISONS plc (GB) | 1988-04-06 | — | — | EP | disclosed |