Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 8/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.47 |
| ▸ | NQO2 | P16083 | 6/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | CYP24A1 | Q07973 | 2/20 | 0.43 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.43 |
| ▸ | CYP27A1 | Q02318 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4098450 | 0.90 | CYP24A1 (0.54) | CYP19A1ACHEMTNR1AMTNR1BNQO2 | |
| SCHEMBL1877585 | 0.84 | ACHE (0.52) | CYP19A1ACHEMTNR1AMTNR1BNQO2 | |
| SCHEMBL7979383 | 0.84 | CYP19A1 (0.55) | CYP19A1ACHEMTNR1AMTNR1BCYP24A1 | |
| SCHEMBL31366772 | 0.84 | ACHE (0.52) | CYP19A1ACHEMTNR1AMTNR1BNQO2 | |
| SCHEMBL345475 | 0.83 | ACHE (0.51) | CYP19A1ACHEMTNR1AMTNR1BNQO2 | |
| SCHEMBL13254661 | 0.82 | MAPK1 (0.53) | CYP19A1ACHEMTNR1AMTNR1BMETAP1 | |
| SCHEMBL14469511 | 0.82 | MAPK1 (0.53) | CYP19A1ACHEMTNR1AMTNR1BMETAP1 | |
| SCHEMBL31366725 | 0.80 | CYP19A1 (0.51) | CYP19A1ACHECYP24A1CYP26A1CYP27A1 | |
| SCHEMBL8435265 | 0.79 | ALDH1A1 (0.56) | CYP19A1ACHEMTNR1AMTNR1BNQO2 | |
| SCHEMBL31650300 | 0.77 | CYP19A1 (0.48) | CYP19A1ACHEMTNR1AMTNR1BNQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4916148-A | AROMATASE INHIBITORS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-04-10 | — | — | US | disclosed |
| EP-0316097-A1 | Naphtho(2,1-b)furan derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-05-17 | — | — | EP | disclosed |