Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 8/20 | 0.43 |
| ▸ | RAB9A | P51151 | 8/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10335047 | 0.89 | HTR2B (0.43) | PPARAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL10334527 | 0.85 | HTR2B (0.41) | PPARAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL10334538 | 0.81 | KDM4E (0.38) | PPARAKMT2AMEN1NPC1RAB9A | |
| SCHEMBL3518868 | 0.79 | NPC1 (0.41) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10334239 | 0.78 | NPC1 (0.40) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1986826 | 0.77 | ALOX15 (0.44) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL19469635 | 0.75 | ALOX5 (0.41) | PPARAKMT2AMEN1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL10335958 | 0.75 | ALOX15 (0.43) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3379747 | 0.75 | CYP3A4 (0.44) | NPC1RAB9AHTR2BSIGMAR1TP53 | |
| SCHEMBL10334288 | 0.74 | AKR1B1 (0.40) | PPARANPC1RAB9ASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4948797-A | 2,2-disubstitued 2,3-dihydro-1,4-benzodioxin derivatives having hypotensive activity | ISTITUTO LUSO FARMACO D'ITALIA S.P.A. (IT) | 1990-08-14 | — | — | US | disclosed |