Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 4/20 | 0.64 |
| ▸ | XDH | P47989 | 1/20 | 0.62 |
| ▸ | NQO2 | P16083 | 2/20 | 0.61 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TTR | P02766 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MMP2 | P08253 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | THRB | P10828 | 2/20 | 0.55 |
| ▸ | MMP9 | P14780 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10335332 | 1.00 | LCK (0.64) | LCKXDHNQO2MAOBPTGS1 | |
| (E)-3,4-Stilbendiol SCHEMBL1821396 | 0.91 | LCK (0.77) | LCKNQO2PTGS1KDM4EHSD17B10 | |
| (E)-3,4-Stilbendiol SCHEMBL1821395 | 0.91 | LCK (0.77) | LCKNQO2PTGS1KDM4EHSD17B10 | |
| SCHEMBL10335571 | 0.82 | LCK (0.94) | LCKXDHNQO2PTGS1KDM4E | |
| SCHEMBL1931423 | 0.80 | LCK (0.81) | LCKXDHNQO2PTGS1KDM4E | |
| SCHEMBL30631591 | 0.79 | LCK (1.00) | LCKXDHNQO2PTGS1KDM4E | |
| SCHEMBL1824176 | 0.79 | LCK (1.00) | LCKXDHNQO2PTGS1KDM4E | |
| SCHEMBL1824175 | 0.79 | LCK (1.00) | LCKXDHNQO2PTGS1KDM4E | |
| SCHEMBL31706727 | 0.79 | LCK (1.00) | LCKXDHNQO2PTGS1KDM4E | |
| SCHEMBL7620505 | 0.79 | MAOB (0.93) | MAOBALDH1A1LMNAPOLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0290442-A4 | PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS. | CHEMEX PHARMACEUTICALS INC (US) | 1990-07-03 | — | — | EP | claimed |
| EP-0290442-A1 | PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS | CHEMEX PHARMACEUTICALS, INC. (US) | 1988-11-17 | — | — | EP | claimed |
| WO-1988003805-A1 | PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS | CHEMEX PHARMACEUTICALS, INC. (US) | 1988-06-02 | — | — | WO | claimed |
| US-11160767-B2 | 4,4′-trans-dihydroxystilbene for use in treating cancer | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2021-11-02 | — | — | US | disclosed |
| US-11160767-B2 | 4,4′-trans-dihydroxystilbene for use in treating cancer | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) | 2021-11-02 | — | — | US | disclosed |
| US-20210113487-A1 | 4,4'-Trans-dihydroxystilbene for Use in Treating Cancer | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION | 2021-04-22 | — | — | US | disclosed |
| US-20210113487-A1 | 4,4'-Trans-dihydroxystilbene for Use in Treating Cancer | THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION | 2021-04-22 | — | — | US | disclosed |
| EP-0290442-A4 | PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS. | CHEMEX PHARMACEUTICALS INC (US) | 1990-07-03 | — | — | EP | disclosed |
| EP-0290442-A1 | PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS | CHEMEX PHARMACEUTICALS, INC. (US) | 1988-11-17 | — | — | EP | disclosed |
| WO-1988003805-A1 | PHARMACOLOGICALLY ACTIVE COMPOUNDS AND MIXTURES THEREOF, ORGANIC COMPOSITIONS AND METAL SALTS | CHEMEX PHARMACEUTICALS, INC. (US) | 1988-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11160767-B2 | 4,4′-trans-dihydroxystilbene for use in treating cancer | DDB1, TOP2B, OGG1 | LCK 3837/4885XDH 1068/4885NQO2 359/4885 |
| US-20210113487-A1 | 4,4'-Trans-dihydroxystilbene for Use in Treating Cancer | DDB1, OGG1, TOP2B | LCK 3858/4885XDH 1065/4885NQO2 341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.