Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | CASP9 | P55211 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9024831 | 0.92 | ALDH1A1 (0.54) | ALDH1A1USP2NPSR1GAAESR1 | |
| SCHEMBL19212315 | 0.90 | ESR1 (0.48) | ALDH1A1USP2NPSR1GAAESR1 | |
| SCHEMBL9449949 | 0.86 | ALDH1A1 (0.46) | ALDH1A1USP2NPSR1GAAESR1 | |
| SCHEMBL19212279 | 0.86 | USP2 (0.44) | ALDH1A1USP2NPSR1GAAESR1 | |
| SCHEMBL15018549 | 0.86 | ALDH1A1 (0.46) | ALDH1A1USP2NPSR1GAAESR1 | |
| SCHEMBL9024146 | 0.84 | L3MBTL1 (0.45) | ALDH1A1KDM4ELMNAMAPTMEN1 | |
| SCHEMBL9025222 | 0.83 | LMNA (0.47) | ALDH1A1HPGDKDM4ESMN1; SMN2HSD17B10 | |
| SCHEMBL5460045 | 0.81 | L3MBTL1 (0.65) | ALDH1A1HPGDKDM4ESMN1; SMN2MAPT | |
| SCHEMBL2010417 | 0.79 | USP2 (0.67) | ALDH1A1USP2NPSR1GAAABCB1 | |
| SCHEMBL3463637 | 0.78 | GLA (0.45) | ALDH1A1NPSR1GAAESR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0289506-A4 | LIPOXYGENASE INHIBITORS | — | 1990-12-12 | — | — | EP | disclosed |
| EP-0289506-A1 | LIPOXYGENASE INHIBITORS | CHEMEX PHARMACEUTICALS, INC. (US) | 1988-11-09 | — | — | EP | disclosed |
| WO-1988003800-A1 | LIPOXYGENASE INHIBITORS | CHEMEX PHARMACEUTICALS, INC. (US) | 1988-06-02 | — | — | WO | disclosed |
| US-4708964-A | Lipoxygenase inhibitors | CHEMEX PHARMACEUTICALS (US) | 1987-11-24 | — | — | US | disclosed |