Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.49 |
| ▸ | DBH | P09172 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | FDPS | P14324 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GRK2 | P25098 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9621820 | 0.90 | DBH (0.54) | ALDH1A1DBHKMT2AHTTGRK2 | |
| SCHEMBL9621670 | 0.75 | ALDH1A1 (0.55) | ALDH1A1DBHKMT2AHTTMAPT | |
| SCHEMBL9837829 | 0.75 | ALDH1A1 (0.42) | ALDH1A1DBHKMT2AHTTTDP1 | |
| SCHEMBL29400600 | 0.74 | ALDH1A1 (0.68) | ALDH1A1MEN1KMT2APOLBHPGD | |
| SCHEMBL7531959 | 0.74 | ALDH1A1 (0.68) | ALDH1A1MEN1KMT2APOLBHPGD | |
| SCHEMBL435689 | 0.74 | ALDH1A1 (0.68) | ALDH1A1MEN1KMT2APOLBHPGD | |
| SCHEMBL9622057 | 0.73 | DBH (0.51) | ALDH1A1DBHKMT2AHTTTDP1 | |
| SCHEMBL9838126 | 0.73 | ALDH1A1 (0.71) | ALDH1A1KMT2APOLBHPGDHTT | |
| SCHEMBL10594119 | 0.71 | DBH (0.51) | DBHCYP17A1 | |
| SCHEMBL19924915 | 0.69 | BRD4 (0.67) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288488-A4 | DOPAMINE- -HYDROXYLASE INHIBITORS | — | 1990-09-12 | — | — | EP | disclosed |
| EP-0288488-A1 | DOPAMINE- -HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1988-11-02 | — | — | EP | disclosed |
| WO-1988001267-A1 | DOPAMINE-ss-HYDROXYLASE INHIBITORS | SMITHKLINE BECKMAN CORPORATION (US) | 1988-02-25 | — | — | WO | disclosed |