SCHEMBL103374

SCHEMBL103374

COCCNCc1ccc(Br)nc1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.50
CD274 Q9NZQ7 2/20 0.46
PDCD1 Q15116 1/20 0.46
P4HTM Q9NXG6 1/20 0.42
BRAF P15056 1/20 0.40
HDAC1 Q13547 2/20 0.39
PIK3CD O00329 1/20 0.39
PIK3CA P42336 1/20 0.39
PIK3CB P42338 1/20 0.39
PIK3CG P48736 1/20 0.39
HTT P42858 1/20 0.39
MEN1 O00255 1/20 0.38
ALDH1A1 P00352 1/20 0.38
KMT2A Q03164 1/20 0.38
IL6 P05231 1/20 0.38
TLR7 Q9NYK1 1/20 0.38
KDM4E B2RXH2 1/20 0.38
GLA P06280 1/20 0.38
DRD4 P21917 1/20 0.37
RAD52 P43351 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29487186 1.00 L3MBTL1 (0.50) L3MBTL1CD274PDCD1P4HTMBRAF
Cadaverine Tartrate SCHEMBL30529687 0.87 CD274 (0.48) L3MBTL1CD274PDCD1P4HTMHDAC1
SCHEMBL2535399 0.86 L3MBTL1 (0.40) L3MBTL1CD274PDCD1HDAC1MEN1
SCHEMBL12558344 0.84 L3MBTL1 (0.50) L3MBTL1CD274PDCD1P4HTMBRAF
SCHEMBL171901 0.82 L3MBTL1 (0.51) L3MBTL1CD274PDCD1P4HTMBRAF
SCHEMBL18291272 0.81 L3MBTL1 (0.50) L3MBTL1CD274PDCD1P4HTMBRAF
SCHEMBL20037908 0.81 L3MBTL1 (0.50) L3MBTL1CD274PDCD1P4HTMBRAF
SCHEMBL3617576 0.81 L3MBTL1 (0.54) L3MBTL1CD274PDCD1P4HTMHTT
SCHEMBL6508504 0.80 DRD4 (0.64) HDAC1DRD4
SCHEMBL7304460 0.79 CYP1A2 (0.54) KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114573553-B Heteroaromatic ring derivative and preparation method and application thereof 广州六顺生物科技有限公司 2023-11-10 CN disclosed
WO-2023155777-A1 N- [ (6-BROMOPYRIDIN-3-YL) METHYL] -2-METHOXYETHAN-1-AMINE SALTS AND PREPARATION THEREOF BEIGENE (SUZHOU) CO., LTD. (CN) 2023-08-24 WO disclosed
WO-2023155777-A1 N- [ (6-BROMOPYRIDIN-3-YL) METHYL] -2-METHOXYETHAN-1-AMINE SALTS AND PREPARATION THEREOF BEIGENE (SUZHOU) CO., LTD. (CN) 2023-08-24 WO disclosed
US-20230172914-A1 BIOMARKER-BASED THERAPEUTIC COMPOSITION WELLMARKER BIO CO., LTD. (KR) 2023-06-08 US disclosed
US-20230022859-A1 TREATMENT OF CANCER WITH ANTI-OX40 ANTIBODIES AND MULTI-KINASE INHIBITORS BEIGENE, LTD. (KY) 2023-01-26 US disclosed
US-20220402936-A1 CRYSTALLINE FORM OF A MULTI-TYROSINE KINASE INHIBITOR, METHOD OF PREPARATION, AND USE THEREOF Mirati Therapeutics, Inc. 2022-12-22 US disclosed
US-20220387404-A1 TREATMENT OF CANCER USING A COMBINATION COMPRISING MULTI-TYROSINE KINASE INHIBITOR AND IMMUNE CHECKPOINT INHIBITOR BEIGENE, LTD. (KY) 2022-12-08 US disclosed
US-11447500-B2 Thienopyridine derivatives and pharmaceutical composition comprising same WELLMARKER BIO CO., LTD. (KR) 2022-09-20 US disclosed
CN-111295386-B Thienopyridine derivatives and pharmaceutical compositions containing the same 伟迈可生物有限公司 2022-09-06 CN disclosed
EP-4011885-A1 OXO-PYRIDINE FUSION RING DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME Wellmarker Bio Co., Ltd. (KR) 2022-06-15 EP disclosed
US-20090286984-A1 Processes and intermediates for preparing fused heterocyclic kinase inhibitors Mirati Therapeutics, Inc. 2009-11-19 US disclosed
US-20090286984-A1 Processes and intermediates for preparing fused heterocyclic kinase inhibitors Mirati Therapeutics, Inc. 2009-11-19 US disclosed
US-20090286984-A1 Processes and intermediates for preparing fused heterocyclic kinase inhibitors Mirati Therapeutics, Inc. 2009-11-19 US disclosed
US-20090264440-A1 INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY Mirati Therapeutics, Inc. 2009-10-22 US disclosed
US-20090264440-A1 INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY Mirati Therapeutics, Inc. 2009-10-22 US disclosed
US-20090264440-A1 INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY Mirati Therapeutics, Inc. 2009-10-22 US disclosed
WO-2009109035-A1 INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY METHYLGENE INC. (CA) 2009-09-11 WO disclosed
WO-2009026717-A1 INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY METHYLGENE INC. (CA) 2009-03-05 WO disclosed
WO-2009026720-A1 PROCESSES AND INTERMEDIATES FOR PREPARING FUSED HETEROCYCLIC KINASE INHIBITORS METHYLGENE INC. (CA) 2009-03-05 WO disclosed
WO-2009026720-A1 PROCESSES AND INTERMEDIATES FOR PREPARING FUSED HETEROCYCLIC KINASE INHIBITORS METHYLGENE INC. (CA) 2009-03-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220387404-A1 TREATMENT OF CANCER USING A COMBINATION COMPRISING MULTI-TYROSINE KINASE INHIBITOR AND IMMUNE CHECKPOINT INHIBITOR PDCD1, LCK, CD274 L3MBTL1 2924/4885CD274 3/4885PDCD1 1/4885
US-20230022859-A1 TREATMENT OF CANCER WITH ANTI-OX40 ANTIBODIES AND MULTI-KINASE INHIBITORS TNFRSF9, TNFRSF1A, TNFSF11 L3MBTL1 2199/4885CD274 6/4885PDCD1 44/4885
US-11447500-B2 Thienopyridine derivatives and pharmaceutical composition comprising same MAP4K5, MAP4K2, MAP3K9 L3MBTL1 4523/4885CD274 4380/4885PDCD1 1389/4885
US-20090286984-A1 Processes and intermediates for preparing fused heterocyclic kinase inhibitors MAP3K19, MAP3K9, MAP4K2 L3MBTL1 3216/4885CD274 2250/4885PDCD1 802/4885
US-20090264440-A1 INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY HGF, ERBB2, MET L3MBTL1 3690/4885CD274 984/4885PDCD1 1293/4885
US-20230172914-A1 BIOMARKER-BASED THERAPEUTIC COMPOSITION KRAS, RET, NRAS L3MBTL1 4139/4885CD274 3951/4885PDCD1 2061/4885
US-20220402936-A1 CRYSTALLINE FORM OF A MULTI-TYROSINE KINASE INHIBITOR, METHOD OF PREPARATION, AND USE THEREOF ABL1, LCK, SRC L3MBTL1 4819/4885CD274 1403/4885PDCD1 911/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.