SCHEMBL10337461

SCHEMBL10337461

N#CCNSCc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.42
MAOA P21397 2/20 0.42
IDO1 P14902 2/20 0.41
CTSK P43235 3/20 0.40
CYP3A4 P08684 2/20 0.39
KDM4E B2RXH2 1/20 0.39
MAPT P10636 1/20 0.39
CTSS P25774 2/20 0.37
MCL1 Q07820 1/20 0.37
ALDH1A1 P00352 2/20 0.36
CYP1A2 P05177 2/20 0.36
MAPK1 P28482 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
CYP1A1 P04798 1/20 0.36
CYP1B1 Q16678 1/20 0.36
CYP2D6 P10635 1/20 0.36
PRMT1 Q99873 1/20 0.36
S100A4 P26447 1/20 0.36
CTSL P07711 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9465554 0.80 BCHE (0.49) CYP3A4KDM4EMAPTALDH1A1CYP1A2
SCHEMBL9366877 0.77 TP53 (0.44) MAOBIDO1CYP3A4KDM4EMAPT
Hydrochloric Acid SCHEMBL11149712 0.75 TP53 (0.42) MAOBIDO1CYP3A4KDM4EMAPT
SCHEMBL28672152 0.74 IDO1 (0.46) MAOAIDO1CYP3A4KDM4EMAPT
Hydrochloric Acid SCHEMBL28151854 0.73 TP53 (0.41) MAOBIDO1CYP3A4KDM4EMAPT
SCHEMBL18962146 0.72 CYP3A4 (0.46) MAOBIDO1CYP3A4KDM4EMAPT
SCHEMBL9465773 0.71 MAOA (0.38) MAOBMAOACTSKCYP3A4KDM4E
Acetonitrile SCHEMBL28296993 0.71 MAOB (0.44) MAOBMAOAIDO1CYP3A4KDM4E
Propionitrile SCHEMBL27536393 0.71 MAOA (0.44) MAOBMAOAIDO1CYP3A4KDM4E
SCHEMBL23133070 0.71 SIGMAR1 (0.46) ALDH1A1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0378707-A1 AMINOACETONITRILE DERIVATIVES. NIPPON SODA CO (JP) 1990-07-25 EP disclosed
WO-1990000543-A1 AMINOACETONITRILE DERIVATIVES NIPPON SODA CO., LTD. (JP) 1990-01-25 WO disclosed