SCHEMBL10338142

SCHEMBL10338142

CC1(C)OCC(COc2cccc3[nH]cc(C=O)c23)O1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 2/20 0.40
MAPK14 Q16539 7/20 0.38
CA2 P00918 1/20 0.36
KCNJ5 P48544 1/20 0.35
KCNJ3 P48549 1/20 0.35
ALDH1A1 P00352 4/20 0.33
NPSR1 Q6W5P4 1/20 0.33
CCNK O75909 1/20 0.33
CDK12 Q9NYV4 1/20 0.33
HTR2A P28223 1/20 0.33
HTR2C P28335 1/20 0.33
HTR2B P41595 1/20 0.33
GLA P06280 1/20 0.33
IMPDH2 P12268 1/20 0.32
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
TP53 P04637 1/20 0.32
CYP3A4 P08684 1/20 0.32
MAPT P10636 1/20 0.32
PKM P14618 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11067767 0.84 CYP2A6 (0.47) CYP2A6ALDH1A1HTR2AHTR2CHTR2B
SCHEMBL4790647 0.81 ALDH1A1 (0.47) MAPK14CA2ALDH1A1GLAMAPT
SCHEMBL5307972 0.81 ALDH1A1 (0.47) MAPK14CA2ALDH1A1GLAMAPT
SCHEMBL5307075 0.81 ALDH1A1 (0.47) MAPK14CA2ALDH1A1GLAMAPT
SCHEMBL29950589 0.74 CYP2A6 (0.54) CYP2A6ALDH1A1HTR2AIMPDH2KDM4E
SCHEMBL9532976 0.72 PDK1 (0.45) MAPK14CA2ALDH1A1GLAKDM4E
SCHEMBL13117591 0.71 MAPK14 (0.42) MAPK14CA2KCNJ5KCNJ3ALDH1A1
SCHEMBL13117584 0.71 MAPK14 (0.42) MAPK14CA2KCNJ5KCNJ3ALDH1A1
SCHEMBL1133830 0.70 ALDH1A1 (0.50) MAPK14ALDH1A1KDM4EMEN1TP53
SCHEMBL7114314 0.70 MAPK14 (0.46) MAPK14CA2KCNJ5KCNJ3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2059555-A None JP disclosed
JP-H0259555-A INDOLE DERIVATIVE KISSEI PHARMACEUT CO LTD 1990-02-28 JP disclosed