Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.57 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 2/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.34 |
| ▸ | TUBB | P07437 | 3/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8705886 | 0.78 | MTNR1A (0.60) | MTNR1AMTNR1BMAPTNPSR1HTR3E | |
| SCHEMBL4384056 | 0.76 | MEN1 (0.47) | MTNR1AMTNR1BMAPTNPSR1HTR3E | |
| SCHEMBL3617254 | 0.75 | MTNR1A (0.53) | MTNR1AMTNR1BMAPTHTR3EHTR3B | |
| SCHEMBL8984805 | 0.73 | MTNR1A (1.00) | MTNR1AMTNR1BNQO2MEN1KMT2A | |
| SCHEMBL3621406 | 0.73 | MTNR1A (0.81) | MTNR1AMTNR1BHTR3EHTR3BHTR3A | |
| SCHEMBL31470868 | 0.72 | MTNR1A (0.53) | MTNR1AMTNR1BHTR3EHTR3BHTR3A | |
| SCHEMBL3621402 | 0.71 | MTNR1A (0.56) | MTNR1AMTNR1BHTR3EHTR3BHTR3A | |
| SCHEMBL8984828 | 0.71 | MTNR1A (0.77) | MTNR1AMTNR1B | |
| SCHEMBL11038251 | 0.69 | VCP (0.48) | MTNR1AMTNR1BEGFRMAPTNPSR1 | |
| SCHEMBL11038249 | 0.69 | VCP (0.48) | MTNR1AMTNR1BEGFRMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0162695-B1 | 6-OXYGENATED-1,3,,4,5-TETRAHYDROBENZ(CD)INDOL-4-AMINES | SMITHKLINE BEECHAM CORPORATION (US) | 1990-01-17 | — | — | EP | disclosed |
| EP-0162695-A1 | 6-Oxygenated-1,3,,4,5-Tetrahydrobenz(cd)indol-4-amines | SMITHKLINE BEECHAM CORPORATION (US) | 1985-11-27 | — | — | EP | disclosed |