Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.40 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10591946 | 0.98 | CA12 (0.44) | CA12CA1CA2CA9SPHK2 | |
| SCHEMBL11727322 | 0.88 | FAAH (0.46) | HSD17B10MEN1KMT2A | |
| SCHEMBL27971354 | 0.82 | SPHK2 (0.44) | CA12CA1CA2CA9SPHK2 | |
| SCHEMBL1206201 | 0.79 | SPHK1 (0.40) | CA12CA1CA9SPHK2SPHK1 | |
| SCHEMBL3080933 | 0.78 | ALDH1A1 (0.36) | CA12CA1CA2CA9SPHK2 | |
| SCHEMBL10892938 | 0.76 | CA12 (0.42) | CA12CA1CA2CA9MGLL | |
| SCHEMBL10975326 | 0.74 | HRH4 (0.38) | CA12CA1CA2CA9ALDH1A1 | |
| SCHEMBL31601713 | 0.73 | MEN1 (0.52) | SPHK2SPHK1DNM1NOS1GRIN2D | |
| SCHEMBL10974724 | 0.73 | CA12 (0.33) | CA12CA1CA2CA9 | |
| SCHEMBL88538 | 0.73 | GRIN2D (0.49) | CA12CA1CA2CA9SPHK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0178121-B1 | IMPROVED FORMULATION OF ANTIINFLAMMATORY DRUGS | PFIZER INC. (US) | 1990-06-13 | — | — | EP | disclosed |
| EP-0178822-B1 | 2-GUANIDINO-4-(2-METHYL-4-IMIDAZOLYL)THIAZOLES IN THE TREATMENT OF RHEUMATOID ARTHRITIS | PFIZER INC. (US) | 1990-01-17 | — | — | EP | disclosed |
| US-4636498-A | OXICAMS, ANTIULCER, ANTISECRETORY 2-GUANIDINO-4-(4-IMIDAZOLYL) THIAZOLES | PFIZER INC. (US) | 1987-01-13 | — | — | US | disclosed |
| US-4591595-A | 2-guanidino-4-(2-methyl-4-imidazolyl)thiazoles in the treatment of rheumatoid arthritis | PFIZER INC. (US) | 1986-05-27 | — | — | US | disclosed |
| EP-0178822-A2 | 2-Guanidino-4-(2-methyl-4-imidazolyl)thiazoles in the treatment of rheumatoid arthritis | PFIZER INC. (US) | 1986-04-23 | — | — | EP | disclosed |
| EP-0178121-A2 | Improved formulation of antiinflammatory drugs | PFIZER INC. (US) | 1986-04-16 | — | — | EP | disclosed |