SCHEMBL10340434

SCHEMBL10340434

N#Cc1ccc(N=NO)nc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.40
KDM4E B2RXH2 4/20 0.40
L3MBTL1 Q9Y468 3/20 0.40
CA12 O43570 1/20 0.35
CA2 P00918 1/20 0.35
CA3 P07451 1/20 0.35
CA6 P23280 1/20 0.35
CA9 Q16790 1/20 0.35
CA14 Q9ULX7 1/20 0.35
LMNA P02545 1/20 0.35
GAA P10253 1/20 0.35
CYP19A1 P11511 1/20 0.34
EGLN2 Q96KS0 1/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
GRM5 P41594 1/20 0.33
NOS3 P29474 2/20 0.32
NOS1 P29475 2/20 0.32
MMP3 P08254 1/20 0.32
ENPP2 Q13822 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19418221 0.81 ALDH1A1 (0.40) ALDH1A1KDM4EL3MBTL1CA12CA2
SCHEMBL23019286 0.76 ALDH1A1 (0.42) ALDH1A1KDM4EL3MBTL1CA12CA2
SCHEMBL28621328 0.73 ALDH1A1 (0.40) ALDH1A1KDM4EL3MBTL1CA12CA2
SCHEMBL1826488 0.73 ALDH1A1 (0.40) ALDH1A1KDM4EL3MBTL1CA12CA2
SCHEMBL15903050 0.72 ALDH1A1 (0.39) ALDH1A1KDM4EL3MBTL1CA12CA2
SCHEMBL1354526 0.70 NOS3 (0.39) ALDH1A1KDM4EL3MBTL1LMNAGAA
SCHEMBL1354527 0.70 NOS3 (0.39) ALDH1A1KDM4EL3MBTL1LMNAGAA
SCHEMBL197468 0.69
SCHEMBL1354532 0.68 GAA (0.43) ALDH1A1KDM4EL3MBTL1LMNAGAA
SCHEMBL1354531 0.68 GAA (0.43) ALDH1A1KDM4EL3MBTL1LMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0181636-B1 2 5-CYANOPYRIDINE-2-DIAZOHYDROXIDE, BASIC SALTS AND METHODS FOR PRODUCTION AND USE UNIV ALABAMA (US) 1990-02-28 EP claimed
US-4816468-A 5-cyanopyridine-2-diazohydroxide, basic salts and use THE UNIVERSITY OF ALABAMA (US) 1989-03-28 US claimed
US-4636564-A ANTITUMOR, ANTIGROWTH AGENTS BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) 1987-01-13 US claimed
EP-0181636-A2 2 5-Cyanopyridine-2-diazohydroxide, basic salts and methods for production and use THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) 1986-05-21 EP claimed
EP-0181636-B1 2 5-CYANOPYRIDINE-2-DIAZOHYDROXIDE, BASIC SALTS AND METHODS FOR PRODUCTION AND USE UNIV ALABAMA (US) 1990-02-28 EP disclosed
EP-0181636-B1 2 5-CYANOPYRIDINE-2-DIAZOHYDROXIDE, BASIC SALTS AND METHODS FOR PRODUCTION AND USE UNIV ALABAMA (US) 1990-02-28 EP disclosed
US-4816468-A 5-cyanopyridine-2-diazohydroxide, basic salts and use THE UNIVERSITY OF ALABAMA (US) 1989-03-28 US disclosed
US-4816468-A 5-cyanopyridine-2-diazohydroxide, basic salts and use THE UNIVERSITY OF ALABAMA (US) 1989-03-28 US disclosed
US-4636564-A ANTITUMOR, ANTIGROWTH AGENTS BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) 1987-01-13 US disclosed
US-4636564-A ANTITUMOR, ANTIGROWTH AGENTS BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) 1987-01-13 US disclosed
EP-0181636-A2 2 5-Cyanopyridine-2-diazohydroxide, basic salts and methods for production and use THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) 1986-05-21 EP disclosed
EP-0181636-A2 2 5-Cyanopyridine-2-diazohydroxide, basic salts and methods for production and use THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) 1986-05-21 EP disclosed