Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 12/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | HSD11B2 | P80365 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1033279 | 0.90 | HSD11B1 (0.46) | HSD11B1EPHX2HSD11B2L3MBTL1 | |
| SCHEMBL4215784 | 0.69 | HSD11B1 (0.53) | HSD11B1EPHX2HSD11B2L3MBTL1 | |
| SCHEMBL4215786 | 0.69 | HSD11B1 (0.53) | HSD11B1EPHX2L3MBTL1 | |
| SCHEMBL1036010 | 0.68 | HSD11B1 (0.58) | HSD11B1EPHX2 | |
| SCHEMBL1034049 | 0.68 | HSD11B1 (0.46) | HSD11B1EPHX2EPHX1HSD11B2L3MBTL1 | |
| SCHEMBL1700055 | 0.67 | EPHX2 (0.36) | EPHX2EPHX1 | |
| SCHEMBL16728419 | 0.66 | — | — | |
| SCHEMBL4100277 | 0.66 | HSD11B1 (0.96) | HSD11B1EPHX2 | |
| SCHEMBL16728409 | 0.66 | — | — | |
| SCHEMBL10768733 | 0.65 | EPHX2 (0.57) | HSD11B1EPHX2EPHX1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112062-A1 | Carbamate And Urea Inhibitors Of 11Beta-Hydroxysteroid Dehydrogenase 1 | VITAE PHARMACEUTICALS, INC | 2011-05-12 | — | — | US | disclosed |
| EP-2276730-A2 | CARBAMATE AND UREA INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE 1 | Vitae Pharmaceuticals, Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112062-A1 | Carbamate And Urea Inhibitors Of 11Beta-Hydroxysteroid Dehydrogenase 1 | HSD11B1, HSD3B1, HSD17B1 | HSD11B1 1/4885EPHX2 1689/4885EPHX1 1324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.