Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.56 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15332027 | 0.86 | NPC1 (0.48) | NPC1RAB9APAX8NPBWR1MCHR1 | |
| SCHEMBL15332373 | 0.82 | MAPK14 (0.43) | NPC1RAB9APAX8HTTCYP1A2 | |
| SCHEMBL15330352 | 0.82 | NPBWR1 (0.45) | NPC1RAB9APAX8NPBWR1KMT2A | |
| SCHEMBL3321144 | 0.81 | RAB9A (0.49) | NPC1RAB9APAX8NPBWR1KMT2A | |
| SCHEMBL29955120 | 0.79 | NPC1 (0.51) | NPC1RAB9ANPBWR1MCHR1KMT2A | |
| SCHEMBL15330816 | 0.78 | MAPT (0.54) | NPC1RAB9AKMT2AKDM4EHTT | |
| SCHEMBL15331298 | 0.77 | LMNA (0.43) | NPC1RAB9ANPBWR1MCHR1KDM4E | |
| SCHEMBL15331012 | 0.76 | ERN1 (0.39) | NPBWR1MCHR1NPSR1ALDH1A1 | |
| SCHEMBL2554507 | 0.75 | PTGS1 (0.36) | NPC1RAB9ANPBWR1MCHR1KMT2A | |
| SCHEMBL15332330 | 0.74 | NPC1 (0.44) | NPC1RAB9ANPBWR1MCHR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0177242-B1 | POLLEN FORMATION INHIBITING PYRAZOLES | ELI LILLY AND COMPANY (US) | 1990-01-03 | — | — | EP | disclosed |
| US-4775409-A | PREVENTING POLLEN FORMATION | ELI LILLY AND COMPANY (US) | 1988-10-04 | — | — | US | disclosed |
| US-4666504-A | HYBRIDS | ELI LILLY AND COMPANY (US) | 1987-05-19 | — | — | US | disclosed |
| EP-0177242-A2 | Pollen formation inhibiting pyrazoles | ELI LILLY AND COMPANY (US) | 1986-04-09 | — | — | EP | disclosed |