Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL543048 | 0.94 | LMNA (0.48) | LMNAHTTAKR1B10MAPTAKR1A1 | |
| SCHEMBL102280 | 0.91 | LMNA (0.50) | LMNAHTTMAPTAKR1B1MEN1 | |
| SCHEMBL104120 | 0.84 | LMNA (0.47) | LMNAAKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL101672 | 0.84 | LMNA (0.47) | LMNAAKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL4317934 | 0.83 | LMNA (0.46) | LMNAAKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL542638 | 0.78 | AKR1B10 (0.39) | LMNAAKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL542293 | 0.78 | AKR1B10 (0.39) | LMNAAKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL542424 | 0.78 | POLB (0.40) | LMNAAKR1B10MAPTAKR1A1AKR1B1 | |
| SCHEMBL105693 | 0.78 | AKR1B1 (0.43) | LMNAAKR1B1MEN1KMT2A | |
| SCHEMBL542461 | 0.76 | AKR1B10 (0.40) | LMNAAKR1B10MAPTAKR1A1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2426113-B1 | CARBINOL COMPOUND HAVING HETEROCYCLIC LINKER | KOWA CO (JP) | 2013-11-06 | — | — | EP | disclosed |
| US-8551985-B2 | Carbinol derivatives having heterocyclic linker | KOWA COMPANY, LTD. (JP) | 2013-10-08 | — | — | US | disclosed |
| EP-2248811-B1 | 2-OXOCHROMENE DERIVATIVE | KOWA CO (JP) | 2012-11-14 | — | — | EP | disclosed |
| US-8168666-B2 | Substituted carbinol compound | KOWA COMPANY, LTD. (JP) | 2012-05-01 | — | — | US | disclosed |
| US-8153634-B2 | Carbinol derivatives having cyclic linker | KOWA COMPANY, LTD. (JP) | 2012-04-10 | — | — | US | disclosed |
| EP-2426113-A1 | CARBINOL COMPOUND HAVING HETEROCYCLIC LINKER | Kowa Company, Ltd. (JP) | 2012-03-07 | — | — | EP | disclosed |
| EP-2098515-B1 | SUBSTITUTED CARBINOL COMPOUND | KOWA CO (JP) | 2012-02-08 | — | — | EP | disclosed |
| US-8008306-B2 | Quinoline compounds | KOWA COMPANY, LTD. (JP) | 2011-08-30 | — | — | US | disclosed |
| US-7919509-B2 | 2-oxochromene derivatives | KOWA COMPANY, LTD. (JP) | 2011-04-05 | — | — | US | disclosed |
| EP-2281817-A1 | SUBSTITUTED CARBINOL COMPOUND HAVING CYCLIC LINKER | Kowa Company, Ltd. (JP) | 2011-02-09 | — | — | EP | disclosed |
| EP-2272843-A1 | QUINOLINE COMPOUND | Kowa Company, Ltd. (JP) | 2011-01-12 | — | — | EP | disclosed |
| EP-2248811-A1 | 2-OXOCHROMENE DERIVATIVE | Kowa Company, Ltd. (JP) | 2010-11-10 | — | — | EP | disclosed |
| US-20100280013-A1 | CARBINOL DERIVATIVES HAVING HETEROCYCLIC LINKER | KOWA COMPANY, LTD. (JP) | 2010-11-04 | — | — | US | disclosed |
| US-20100063119-A1 | SUBSTITUTED CARBINOL COMPOUND | KOWA COMPANY, LTD. (JP) | 2010-03-11 | — | — | US | disclosed |
| US-20100048610-A1 | CARBINOL DERIVATIVES HAVING CYCLIC LINKER | KOWA COMPANY, LTD. (JP) | 2010-02-25 | — | — | US | disclosed |
| US-20100016327-A1 | QUINOLINE COMPOUNDS | KOWA COMPANY, LTD. (JP) | 2010-01-21 | — | — | US | disclosed |
| US-20090286780-A1 | 2-OXOCHROMENE DERIVATIVES | KOWA COMPANY, LTD. (JP) | 2009-11-19 | — | — | US | disclosed |
| EP-2098515-A1 | SUBSTITUTED CARBINOL COMPOUND | Kowa Company. Ltd. (JP) | 2009-09-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280013-A1 | CARBINOL DERIVATIVES HAVING HETEROCYCLIC LINKER | NR1H2, NR1H3, CCR2 | LMNA 1575/4885HTT 2209/4885AKR1B10 495/4885 |
| US-20100063119-A1 | SUBSTITUTED CARBINOL COMPOUND | NR1H2, NR1H3, CYP46A1 | LMNA 1674/4885HTT 2349/4885AKR1B10 496/4885 |
| US-20100048610-A1 | CARBINOL DERIVATIVES HAVING CYCLIC LINKER | NR1H2, NR1H3, LDLR | LMNA 1288/4885HTT 3382/4885AKR1B10 443/4885 |
| US-20090286780-A1 | 2-OXOCHROMENE DERIVATIVES | NR1H2, NR1H3, CYP46A1 | LMNA 1961/4885HTT 2414/4885AKR1B10 280/4885 |
| US-20100016327-A1 | QUINOLINE COMPOUNDS | NR1H2, NR1H3, LDLR | LMNA 1606/4885HTT 1838/4885AKR1B10 838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.