Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 18/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10340974 | 1.00 | CA2 (0.47) | CA2CA12CA1CA9ESR2 | |
| SCHEMBL31028770 | 0.91 | CA2 (0.53) | CA2CA12CA1CA9 | |
| SCHEMBL10370977 | 0.78 | LOX (0.45) | CA2CA12CA1CA9 | |
| SCHEMBL10370976 | 0.78 | LOX (0.45) | CA2CA12CA1CA9 | |
| SCHEMBL10371025 | 0.74 | CA2 (0.48) | CA2CA12CA1CA9 | |
| SCHEMBL10371026 | 0.74 | CA2 (0.48) | CA2CA12CA1CA9 | |
| SCHEMBL19400089 | 0.72 | ATIC (0.46) | CA2CA12CA1CA9 | |
| SCHEMBL29226441 | 0.72 | CA12 (0.36) | CA2CA12CA1CA9 | |
| SCHEMBL30844188 | 0.72 | LOX (0.41) | CA2CA12CA1CA9 | |
| SCHEMBL10372585 | 0.69 | CA2 (0.43) | CA2CA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0221806-B1 | SUBSTITUTED THIOPHENE-2-SULFANOMIDE AND ANTIGLAUCOMA COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1990-01-10 | — | — | EP | disclosed |
| EP-0221806-A1 | Substituted thiophene-2-sulfanomide and antiglaucoma compositions containing them | MERCK & CO. INC. (US) | 1987-05-13 | — | — | EP | disclosed |
| US-4665090-A | TOPICAL ADMINISTRATION | MERCK & CO., INC. (US) | 1987-05-12 | — | — | US | disclosed |