Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOX | P28300 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 18/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10370977 | 1.00 | LOX (0.45) | LOXLOXL2CA2CA12CA1 | |
| SCHEMBL10340975 | 0.78 | CA2 (0.47) | CA2CA12CA1CA9 | |
| SCHEMBL10340974 | 0.78 | CA2 (0.47) | CA2CA12CA1CA9 | |
| SCHEMBL10371025 | 0.73 | CA2 (0.48) | CA2CA12CA1CA9 | |
| SCHEMBL10371026 | 0.73 | CA2 (0.48) | CA2CA12CA1CA9 | |
| SCHEMBL29512689 | 0.73 | LOXL2 (0.47) | LOXLOXL2 | |
| SCHEMBL19400089 | 0.71 | ATIC (0.46) | CA2CA12CA1CA9 | |
| SCHEMBL29512780 | 0.69 | HPGD (0.53) | LOXLOXL2 | |
| SCHEMBL24195873 | 0.69 | LOX (0.44) | LOXLOXL2 | |
| SCHEMBL10372585 | 0.68 | CA2 (0.43) | CA2CA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0182691-B1 | SUBSTITUTED THIOPHENE-2-SULFONAMIDES AND THEIR PREPARATION | MERCK & CO. INC. (US) | 1990-07-04 | — | — | EP | claimed |
| EP-0182691-A1 | Substituted thiophene-2-sulfonamides and their preparation | MERCK & CO. INC. (US) | 1986-05-28 | — | — | EP | claimed |
| EP-0182691-B1 | SUBSTITUTED THIOPHENE-2-SULFONAMIDES AND THEIR PREPARATION | MERCK & CO. INC. (US) | 1990-07-04 | — | — | EP | disclosed |
| US-4721794-A | Substituted thiophene-2-sulfonamide antiglaucoma agents | MERCK & CO., INC. (US) | 1988-01-26 | — | — | US | disclosed |
| EP-0182691-A1 | Substituted thiophene-2-sulfonamides and their preparation | MERCK & CO. INC. (US) | 1986-05-28 | — | — | EP | disclosed |