Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 4/20 | 0.51 |
| ▸ | MAOB | P27338 | 4/20 | 0.50 |
| ▸ | MAOA | P21397 | 3/20 | 0.50 |
| ▸ | PARP15 | Q460N3 | 5/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1033318 | 0.83 | MAOA (0.46) | MAOBMAOAPARP15PARP10HPGD | |
| SCHEMBL7649580 | 0.82 | MAOA (0.56) | MAOBMAOAPARP15PARP10HRH3 | |
| SCHEMBL10249569 | 0.78 | MAOA (0.61) | MAOBMAOAPARP15PARP10HRH3 | |
| SCHEMBL15818207 | 0.78 | MAOB (0.60) | MAOBMAOA | |
| SCHEMBL1028352 | 0.75 | MAOB (0.67) | HSD17B1MAOBMAOAHPGD | |
| SCHEMBL28655414 | 0.74 | HSD17B1 (0.78) | HSD17B1MAOBMAOAPARP10HRH3 | |
| SCHEMBL2592073 | 0.74 | HSD17B1 (0.48) | HSD17B1PARP15PARP10HPGD | |
| SCHEMBL1745460 | 0.74 | HSD17B1 (0.63) | HSD17B1CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL23483166 | 0.74 | LTA4H (0.56) | MAOBMAOAPARP15PARP10HRH3 | |
| SCHEMBL17361548 | 0.73 | MAOB (0.54) | MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581509-B1 | 1-(AMINO)INDANES AS EDG RECEPTOR AGONISTS | MERCK SHARP & DOHME (US) | 2011-01-19 | — | — | EP | disclosed |
| EP-1581509-A4 | 1-(AMINO)INDANES AND (1,2-DIHYDRO-3-AMINO)-BENZOFURANS, BENZOTHIOPHENES AND INDOLES AS EDG RECEPTOR AGONISTS | MERCK & CO INC (US) | 2008-04-23 | — | — | EP | disclosed |
| US-7220734-B2 | 1-(amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles as Edg receptor agonists | MERCK & CO., INC. (US) | 2007-05-22 | — | — | US | disclosed |
| US-20060161005-A1 | 1-(Amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles as edg receptor agonists | MERCK SHARP & DOHME CORP. | 2006-07-20 | — | — | US | disclosed |
| EP-1581509-A2 | 1-(AMINO)INDANES AND (1,2-DIHYDRO-3-AMINO)-BENZOFURANS, BENZOTHIOPHENES AND INDOLES AS EDG RECEPTOR AGONISTS | Merck & Co., Inc. (US) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004058149-A2 | 1-(AMINO)INDANES AND (1,2-DIHYDRO-3-AMINO)-BENZOFURANS, BENZOTHIOPHENES AND INDOLES | MERCK & CO., INC. (US) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060161005-A1 | 1-(Amino)indanes and (1,2-dihydro-3-amino)-benzofurans, benzothiophenes and indoles as edg receptor agonists | IDO1, IDO2, EDNRA | HSD17B1 769/4885MAOB 1511/4885MAOA 1597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.