Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.97 |
| ▸ | THRB | P10828 | 2/20 | 0.97 |
| ▸ | MAPT | P10636 | 1/20 | 0.97 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.97 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.97 |
| ▸ | GABBR2 | O75899 | 7/20 | 0.56 |
| ▸ | GABBR1 | Q9UBS5 | 7/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phaclofen SCHEMBL339995 | 0.98 | LMNA (1.00) | LMNACYP1A2THRBMAPTPMP22 | |
| SCHEMBL1881771 | 0.85 | LMNA (0.76) | LMNACYP1A2THRBMAPTPMP22 | |
| SCHEMBL1893272 | 0.85 | LMNA (0.76) | LMNACYP1A2THRBMAPTPMP22 | |
| SCHEMBL1887532 | 0.85 | LMNA (0.76) | LMNACYP1A2THRBMAPTPMP22 | |
| SCHEMBL6350896 | 0.80 | LMNA (0.68) | LMNACYP1A2THRBMAPTPMP22 | |
| Phaclofen SCHEMBL10343564 | 0.79 | LMNA (0.68) | LMNACYP1A2THRBMAPTPMP22 | |
| SCHEMBL10507284 | 0.77 | GABBR2 (0.64) | LMNACYP1A2THRBMAPTPMP22 | |
| SCHEMBL21616488 | 0.77 | LMNA (0.64) | LMNACYP1A2THRBMAPTPMP22 | |
| SCHEMBL28002092 | 0.77 | LMNA (0.64) | LMNACYP1A2THRBMAPTPMP22 | |
| SCHEMBL6361790 | 0.76 | LMNA (0.62) | LMNACYP1A2THRBMAPTPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0181833-B1 | SUBSTITUTED PROPANE-PHOSPHONOUS ACID COMPOUNDS | CIBA-GEIGY AG (CH) | 1990-05-02 | — | — | EP | disclosed |